Evidence map›Paper›PMID 42303764›Full record

ArticleAesthetic plastic surgery2026

Autologous Fat Graft Combined With Botulinum Toxin A Injection for Facial Sunken Deformity Treatment: A Retrospective Clinical Analysis.

Na Wang, Li-Ming Sun, Si-Ming Wei, Shuai Qiang, Jia-Yang Wang, Xian-Hui Zeng, Na Ma, Zhao-Xiang Zhang

Abstract read
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Article in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Na Wang *Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.
Li-Ming Sun *Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.ORCID http://orcid.org/0000-0003-2785-4447
Si-Ming WeiDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.
Shuai QiangDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.
Jia-Yang WangDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.
Xian-Hui ZengDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.
Na MaDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China.
Zhao-Xiang ZhangDepartment of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, No.127 Changle West Road, Xi'an, 710032, Shaanxi, People's Republic of China. chaogai263@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFacial sunken deformity caused by trauma, surgery, or skin disease often leads to aesthetic and functional impairment. Autologous fat grafting is widely used for volume restoration but is challenged by poor graft survival in scarred tissue. Combining fat grafting with botulinum toxin A (BoNTA) may improve graft retention via enhanced vascularization and reduced mechanical tension.

methodsWe retrospectively analyzed 43 patients with facial sunken deformity treated from January 2021 to January 2024. All patients were treated with V-shaped dissector cannula for subscar tissue release, fat harvesting from the abdomen, filtration of lipoaspirate, and fat grafting combined with local BoNTA injection. Outcomes were assessed using pre- and postoperative clinical photographs, 3D facial volumetric scanning, and patient satisfaction over a 6- to 12-month follow-up.

resultsSignificant volume restoration was observed postoperatively with stable long-term outcomes. No serious complications occurred. Patients reported high satisfaction with aesthetic improvement and functional recovery.

conclusionThe combined technique of V-shaped dissector cannula subcision, filtered fat grafting, and local BoNTA injection is a safe and effective method to correct facial sunken deformity, improving fat graft survival and contour restoration. This approach offers a promising option for managing challenging scar-related deformities. IMPORTANT POINTS: This study proposes the following three technical innovations to enhance fat graft survival and improve the appearance of concave scars: (1) using a V-shaped dissector cannula to fully release underlying scar tissue; (2) processing fat using a filter to optimize graft quality; and (3) using botulinum toxin to promote fat vascularization. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Adipose TissueBotulinum Toxins, Type ACicatrixAdultEstheticsFaceFemaleFollow-Up StudiesGraft SurvivalHumansMaleMiddle AgedPatient SatisfactionRetrospective StudiesTransplantation, AutologousTreatment OutcomeBotulinum Toxins, Type AAutologous fat graftBotulinum toxin AFacial sunken deformity

Identifiers

PMID42303764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.