Hyaluronate-coated novasomes as a nanoplatform for targeted delivery of Beta vulgaris subsp. cicla extract: formulation, characterization, and phytochemical profiling.

Doaa A H Deabes, Eman A W El-Abd, Alaa M Saleh, Eman S Shalaby

Abstract read

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Doaa A H DeabesPharmacognosy Department, National Research Centre, 33 El Buhouth St, Dokki, P.O. Box 12622, Giza, Egypt.

Eman A W El-AbdPharmacognosy Department, National Research Centre, 33 El Buhouth St, Dokki, P.O. Box 12622, Giza, Egypt.

Alaa M SalehDepartment of Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth St, Dokki, P.O. Box 12622, Giza, Egypt. alaasaleh011@gmail.com.ORCID http://orcid.org/0000-0002-9076-3102

Eman S ShalabyPharmaceutical Technology Department, National Research Centre, 33 El Buhouth St, Dokki , P.O. Box 12622, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyaluronate-coated novasomes as an eco-innovative delivery system to enhance the antimicrobial and antioxidant efficacy of Beta vulgaris subsp. cicla (BV) aerial parts extracts were developed and characterised in this study. The phytochemical profile was established using GC-MS and LC-MS/MS, along with the isolation of key biomarkers. Two novasome formulations (BV1 and BV2) were synthesized, and the optimized BV1 was subjected to comprehensive characterization, including encapsulation efficiency (EE), particle size, zeta potential, FTIR, and TEM. The biological activities were evaluated via DPPH radical scavenging and agar well assays against Staphylococcus aureus, Escherichia coli, and Candida albicans. GC-MS analysis of the dichloromethane fraction identified 15 compounds (89.64%), dominated by fatty acids: oleic acid (30.52%), palmitic acid (21.92%), and stearic acid (10.50%). LC-MS/MS analysis of the ethanolic extract revealed 33 metabolites, primarily flavonoids and phenolic acids. The isolated compounds included oleanolic acid, campesterol, isovitexin, and apigenin-O-hexoside. While the crude extract exhibited limited antimicrobial activity (effective only against C. albicans), encapsulation within hyaluronate-coated novasomes significantly enhanced its biopotency. BV1 exhibited some inhibitory trends against all tested microorganisms, whereas BV2 was effective only against bacterial strains. Regarding radical scavenging activity, BV1 exhibited significantly higher antioxidant activity (IC

Indexed as

Drug Delivery SystemsHyaluronic AcidPhytochemicalsPlant ExtractsAnti-Infective AgentsAntioxidantsCandida albicansEscherichia coliGas Chromatography-Mass SpectrometryMicrobial Sensitivity TestsStaphylococcus aureusTandem Mass SpectrometryAnti-Infective AgentsAntioxidantsHyaluronic AcidPhytochemicalsPlant ExtractsAntimicrobialAntioxidantGC-MSLC-MS/MSNovasomes

Identifiers

PMID42303711

DOI10.1038/s41598-026-56921-8

PMCPMC13272941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.