Evidence map›Paper›PMID 42303676›Full record

ArticleScientific reports2026

Comparative study on the protective effects of Silybum marianum L. seeds and leaves against nickel chloride induced anemia, liver and kidney injury: an in vivo and in silico approach.

Oumayma Iraqi, Mariam Jalal, Mouloud Lamtai, Oussama Merzouki, Asmae Nouayti, Mohamed Yassine El Brouzi, Hamid Nouayti, Omar Noman, Abdelaaty A Shahat, Amal Dimaoui and 5 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Oumayma IraqiLaboratory of Advanced Materials and Process Engineering, Faculty of Sciences, Ibn Tofaïl University, B.P. 133, 14000, Kenitra, Morocco. oumayma.iraqi@uit.ac.ma.
Mariam JalalLaboratory of Cell Biology and Molecular Genetics, Faculty of Science, Ibnou Zohr University, B.P. 8106, 80000, Agadir, Morocco.
Mouloud LamtaiLaboratory of Biology and Health, Neurosciences, Neuro-immunology and Behavior Unit, Faculty of Science, Ibn Tofail University, Kenitra, Morocco.
Oussama MerzoukiLaboratory of Engineering Electrochemistry, Modeling, and Environment, Faculty of Sciences Dhar Mahraz, Sidi Mohamed Ben Abdellah University, 30000, Fez, Morocco.
Asmae NouaytiEthnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia, Morocco.
Mohamed Yassine El BrouziLaboratory of Biology and Health, Neurosciences, Neuro-immunology and Behavior Unit, Faculty of Science, Ibn Tofail University, Kenitra, Morocco.
Hamid NouaytiDepartment of Bioresources, Biotechnologies, Ethnopharmacology, and Health, Faculty of Sciences Oujda, Mohammed First University, Oujda, Morocco.
Omar NomanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia.
Abdelaaty A ShahatDepartment of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia.
Amal DimaouiLaboratory of Biology and Health, Neurosciences, Neuro-immunology and Behavior Unit, Faculty of Science, Ibn Tofail University, Kenitra, Morocco.
Radoine NouaytiLaboratory of Engineering Sciences and Applications, National School of Applied Sciences, Abdelmalek Essaadi University, 32003, Al- Hoceima, Morocco.
Souhail ChannaouiOasis System Research Unit, Regional Center of Agricultural Research of Errachidia, National Institute of Agricultural Research, PO. Box 415, 10090, Rabat, Morocco.
Joe Miantezila BasiluaDepartment of Biostatistics and Mathematics, Faculty of Pharmacy, Paris Cité University, 4, avenue de l'observatoire, 75006, Paris, France.
Youness TabozLaboratory of natural Resources and Sustainable Development, Research Unit in Nutrition, Metabolism and Physiology Faculty of Sciences, Ibn Tofaïl University, PO Box 133, 14000, Kenitra, Kenitra, Morocco.
Amar HabsaouiLaboratory of Advanced Materials and Process Engineering, Faculty of Sciences, Ibn Tofaïl University, B.P. 133, 14000, Kenitra, Morocco.

Funding

Ongoing Research Funding program, King Saud University, Riyadh (ORF-2026-1057)
6 · The paper itself

Abstract

While nickel is required in trace amounts for human health, excessive exposure can be harmful. It can cause significant damage to the liver, kidneys, and other organs, depending on the route of exposure. The aim of this study is to investigate the protective effect of the Silybum marianum L. seeds and leaves on the liver and kidneys as well as blood parameters. The purpose is to examine whether a one-month dietary supplementation with Silybum marianum L. seeds and leaves could prevent and prepare the body to resist nickel-induced damage. Seed and leaf extracts were administered orally to albino rats for one month. The rats were then exposed intraperitoneally to nickel chloride NiCl

Indexed as

AnemiaChemical and Drug Induced Liver InjuryNickelPlant ExtractsPlant LeavesProtective AgentsSeedsSilybum marianumAnimalsKidneyLiverMaleOxidative StressRatsNickelnickel chloridePlant ExtractsProtective AgentsAMPK/SIRT1Heavy metalsHematotoxicityHepato-renal toxicityOxidative stressSilybum marianum L.

Identifiers

PMID42303676
PMCPMC13538569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.