In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Yun Wang *MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0009-0004-2052-2452 Xianyun Jiang *Department of Chemical Physics, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0009-0001-6725-1926 Xing Liu *MOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-7480-5085 Xin JiangMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0009-0004-6202-2560 Xiyu WangMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0009-0004-6645-6681 Xiaoyu SongMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-7598-0459 Feng ChenMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-0182-5712 Yuanyuan LiuMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Xu-Zhuo GouMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Ai-Hui TangMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0003-3715-6714 Xuebiao YaoMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. yaoxb@ustc.edu.cn.ORCID http://orcid.org/0000-0001-8982-5911 Zhonghuai HouDepartment of Chemical Physics, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China. hzhlj@ustc.edu.cn.ORCID http://orcid.org/0000-0003-1241-7041 Dan LiuMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. dliu919@ustc.edu.cn.ORCID http://orcid.org/0000-0003-4017-3136 Funding
Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2016YFA0101200National Natural Science Foundation of China (National Science Foundation of China) 32090041
6 · The paper itselfAbstract
Histone modifications recruit chromatin regulators, but how their spatial patterns are established on mitotic chromosomes remains unclear. Spatial separation between active chromatin and centromeric signaling is essential for accurate chromosome segregation, yet the physical principles linking epigenetic marks to mitotic protein organization are poorly defined. Here, we show that liquid-liquid phase separation (LLPS) of WDR5, a core component of H3K4 methyltransferase complexes, acts as a spatial organizer of mitotic chromosomes. WDR5 LLPS is driven by multivalent charged and hydrophobic interactions in its N-terminal region. Phase-separated WDR5 repels the chromosomal passenger complex (CPC), segregating H3K4-trimethylated (H3K4me3) chromatin from H3T3-phosphorylated (H3T3ph) centromeric regions. Disrupting WDR5 condensation causes Aurora B mislocalization and chromosome misalignment, and restoring H3K4me3 alone does not rescue these defects. Computational modeling and rescue experiments support that WDR5-driven LLPS and histone modification signals cooperate to concentrate CPC at centromeres, revealing how LLPS and epigenetic information organize chromatin compartments during mitosis.
Indexed as
ChromosomesEpigenesis, GeneticHistone-Lysine N-MethyltransferaseIntracellular Signaling Peptides and ProteinsMitosisAurora Kinase BCentromereChromatinChromosome SegregationHeLa CellsHistonesHumansPhase SeparationPhosphorylationAURKB protein, humanAurora Kinase BChromatinHistone-Lysine N-MethyltransferaseHistonesIntracellular Signaling Peptides and ProteinsWDR5 protein, human
Identifiers
PMID42303627
PMCPMC13434715
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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