Evidence map›Paper›PMID 42303465›Full record

ArticleRNA (New York, N.Y.)2026

The Tor pathway, ribosome concentration, and wobble decoding mediate inhibitory effects of the Leu-Pro CUC-CCG codon pair in

Brandon S Bruno, Evan M Platten, Lisa Houston, Christina E Brule, Elizabeth J Grayhack

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Brandon S Bruno *Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Evan M Platten *Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Lisa HoustonDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Christina E BruleDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA.
Elizabeth J GrayhackDepartment of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA elizabeth_grayhack@urmc.rochester.edu.ORCID http://orcid.org/0000-0003-2400-5490

Funding

Training in Cellular, Biochemical and Molecular SciencesT32GM068411 · NIGMS · UNIVERSITY OF ROCHESTER · PI MAQUAT, LYNNE E · 2005 to 2019
$3.9M
Modulation of translation by synonymous codons in yeastR01GM118386 · NIGMS · UNIVERSITY OF ROCHESTER · PI GRAYHACK, ELIZABETH JOAN · 2016 to 2023
$2.5M
NIGMS NIH HHS R01 GM118386NIGMS NIH HHS T32 GM068411
6 · The paper itself

Abstract

Translation elongation and efficiency are modulated by the genetic code, with reduced translation efficiency and slow translation caused by 17 inhibitory codon pairs in the yeast

Indexed as

CodonRibosomesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsBase PairingBase SequenceProtein BiosynthesisRNA, Transfer, LeuCodonRNA, Transfer, LeuSaccharomyces cerevisiae Proteinsribosome quality controltranslation

Identifiers

PMID42303465
PMCPMC13492127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.