Evidence map›Paper›PMID 42303450›Full record

ArticleGenome research2026

Influence of

Colin J Shew, Gulhan Kaya, Sean P McGinty, Megan Y Dennis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Colin J ShewGenome Center, MIND Institute, Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, California 95616, USA colinshew@gmail.com mydennis@ucdavis.edu.
Gulhan KayaGenome Center, MIND Institute, Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, California 95616, USA.
Sean P McGintyGenome Center, MIND Institute, Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, California 95616, USA.
Megan Y DennisGenome Center, MIND Institute, Department of Biochemistry and Molecular Medicine, University of California, Davis, Davis, California 95616, USA colinshew@gmail.com mydennis@ucdavis.edu.ORCID http://orcid.org/0000-0002-8502-5420

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human-specific segmental duplications (HSDs) contain millions of base pairs of sequence unique to the human genome, including genes that shape neurodevelopment. Despite their young age (<6 million years), HSD genes exhibit widespread regulatory divergence, with paralog-specific expression patterns documented across a variety of tissues and cell types. Using long-read expression and epigenomic data, we show that human-specific paralogs tend to have lower activity than the shared, ancestral ones. To systematically characterize the

Identifiers

PMID42303450
PMCPMC13322076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.