Evidence map›Paper›PMID 42303414›Full record

ArticleLupus science & medicine2026

Stage-resolved mapping of RP105 (CD180)-negative B cells reveals residual plasmablast-lineage skewing in SLE: a cross-sectional study.

Ayana Kanagawa, Akihito Maruyama, Tatsuki Shibuta, Mitsuteru Akahoshi, Sachiko Soejima, Yoshifumi Tada, Syuichi Koarada

Abstract read
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In one paragraph

Article in Lupus science & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ayana KanagawaDepartment of Medical Technology and Sciences, International University of Health and Welfare, Okawa, Japan.
Akihito MaruyamaDepartment of Rheumatology, Faculty of Medicine, Saga University, Saga, Japan.
Tatsuki ShibutaDepartment of Medical Technology and Sciences, International University of Health and Welfare - Fukuoka Campus, Okawa, Japan.
Mitsuteru AkahoshiDepartment of Rheumatology, Faculty of Medicine, Saga University, Saga, Japan.
Sachiko SoejimaDepartment of Rheumatology, Takagi Hospital, Okawa, Japan.
Yoshifumi TadaDepartment of Rheumatology, Takagi Hospital, Okawa, Japan.
Syuichi KoaradaDepartment of Medical Technology and Sciences, International University of Health and Welfare, Okawa, Japan koarada@ihwg.jp.ORCID 0000-0002-4794-8881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether clinically inactive/low-activity SLE reflects immunological remission in this cross-sectional study using CD180 (RP105)-anchored, stage-resolved profiling of peripheral B-cell differentiation.

methodsCD19

resultsActive SLE redistributed towards downstream CD180

conclusionsCD180-anchored, stage-resolved profiling indicates that clinical quiescence may not fully equate to immunological normalisation in SLE. These cross-sectional observations do not establish durable persistence, and longitudinal validation is needed. An upstream CXCR5 decrement detectable even in long-term quiescence is consistent with extrafollicular-leaning priming changes arising before CD180 loss; however, any implications for longitudinal immunomonitoring remain hypothesis-generating.

Indexed as

Antigens, CDB-LymphocytesLupus Erythematosus, SystemicPlasma CellsAdultAntigens, CD19B-Cell Activation Factor ReceptorB-Cell Maturation AntigenCase-Control StudiesCD11c AntigenCell DifferentiationCell LineageCross-Sectional StudiesFemaleFlow CytometryHumansAntigens, CDAntigens, CD19B-Cell Activation Factor ReceptorB-Cell Maturation AntigenCD11c AntigenCD180 protein, humanCXCR5 protein, humanReceptors, CXCR5Autoimmune DiseasesAutoimmunityB-LymphocytesChemokinesSystemic Lupus Erythematosus

Identifiers

PMID42303414
PMCPMC13289216

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.