Evidence map›Paper›PMID 42303380›Full record

ArticleRMD open2026

Elevated plasma monounsaturated fatty acids and their associations with disease activity, adiposity and sex in patients with rheumatoid arthritis: a cross-sectional study.

Shalini Narayana Swamy, Martha A Belury, Rachel M Cole, Kristen Heitman, Steven Pan, Zhibo Yang, Aizhan Karabukayeva, Yang Mao-Draayer, Beatriz Yae Hanaoka

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PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shalini Narayana SwamyDepartment of Medicine, Section of Rheumatology, Immunology and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID http://orcid.org/0009-0007-9383-0247
Martha A BeluryDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.
Rachel M ColeDepartment of Food Science and Technology, The Ohio State University, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0001-5507-9367
Kristen HeitmanDivision of Health Sciences, The Ohio State University, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-5178-9043
Steven PanStephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Zhibo YangDepartment of Biochemistry & Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Aizhan KarabukayevaDepartment of Health Administration & Policy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.ORCID http://orcid.org/0000-0003-2976-4277
Yang Mao-DraayerDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Beatriz Yae HanaokaDepartment of Medicine, Section of Rheumatology, Immunology and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA beatriz-hanaoka@ou.edu.ORCID http://orcid.org/0000-0002-2695-4852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRheumatoid arthritis (RA) is a chronic autoimmune disease associated with systemic inflammation and metabolic alterations that may influence circulating lipid profiles. While polyunsaturated fatty acids have been widely studied, less is known about monounsaturated fatty acids (MUFAs), their endogenous synthesis and their relationships with disease activity and adiposity.

methodsIn this cross-sectional study, 52 individuals with RA and 30 matched controls were recruited (2017-2022). Disease activity (Disease Activity Score in 28 joints-C reactive protein (DAS28-CRP)), body composition and metabolic parameters were assessed. Dietary intake was captured using a 4-day food journal. Plasma fatty acids were measured by gas chromatography and the stearoyl-CoA desaturase-1 (SCD-1) index estimated endogenous MUFA synthesis. Multivariable regression with false discovery rate correction was used.

resultsParticipants with RA had lower insulin sensitivity, higher triglycerides and lower physical activity levels. Plasma oleic and palmitoleic acids and the SCD-1 index were higher in RA, while linoleic and arachidonic acids were lower; saturated and omega-3 fatty acids did not differ. After adjustment for age, sex and diet, oleic acid was associated with RA status (β=1.4; 95% CI 0.33 to 2.5) and waist-to-hip ratio (β=14; 95% CI 6.9 to 21). Among participants with RA, higher oleic acid and gondoic acid were associated with DAS28-CRP, while palmitoleic acid was higher in women but not associated with DAS28-CRP.

conclusionsCirculating MUFAs are associated with RA status, adiposity and disease activity after adjusting for diet, supporting a role for endogenous lipid metabolism in RA.

Indexed as

AdiposityArthritis, RheumatoidFatty Acids, MonounsaturatedAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedSeverity of Illness IndexSex FactorsStearoyl-CoA DesaturaseBiomarkersFatty Acids, MonounsaturatedStearoyl-CoA DesaturaseArthritis, RheumatoidAutoimmune DiseasesBiomarkersInflammationLipids

Identifiers

PMID42303380
PMCPMC13289223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.