ArticleExperimental physiology2026
Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study.
Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both endurance and resistance responses, on muscle protein turnover following hindlimb unloading (HU) remain unexplored. This study investigated the effects of reloading strategies using HT and/or EX on protein synthesis, ribosome biogenesis and autophagic markers. Eight-week-old male C57BL/6J mice underwent HU (3 weeks), HU+HT (1 week, 5 sessions, 30 min, 40°C), HU+EX (5 sessions of high-intensity inclined treadmill running), HU+EX+HT or HU+REL (passive reloading). HU+HT did not induce additional effects compared with the HU+REL group concerning protein synthesis rates, although one marker of protein synthesis (phosphorylated ribosomal protein S6) tended to increase. HU+HT did not lead to an increase in rRNA content. HU+EX induced a concomitant decrease in the mitochondrial fission markers phosphorylated dynamin-related protein 1 and phosphorylated AMP-activated protein kinase, suggesting improved mitochondrial efficiency. However, no additional effects were observed for rRNA or heat shock proteins compared with the HU+REL group. Finally, exercise followed by heat treatment post-HU (HU+EX+HT) appears to be detrimental, as protein synthesis rates did not increase, despite an increase in rRNA content. Thus, at this sampling time point (14 days post-HU), neither heat therapy nor hybrid retraining produced additional effects on the studied markers compared with a normal resumption of activity. In contrast, the sequential application of the two stressors may inhibit post-HU muscle mass recovery, as evidenced by the absence of increased protein synthesis rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.