Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA-Brasil Cohort Study.
Karina P M P Martins, Sandhi M Barreto, Lidyane V Camelo, Sara T Menezes, Naomi M Hamburg, Maria de Fatima H S Diniz, Antonio L P Ribeiro, Luisa C C Brant
Article in Diabetes, obesity & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Karina P M P MartinsFaculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID 0000-0002-8313-7429
Sandhi M BarretoFaculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Lidyane V CameloFaculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Sara T MenezesFaculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Naomi M HamburgWhitaker Cardiovascular Institute, Boston University Chobanian and Avedisian School of Medicine (NMH), Boston, Massachusetts, USA.
Maria de Fatima H S DinizFaculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Antonio L P RibeiroFaculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Luisa C C BrantFaculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Funding
ALPR LCCB CNPq 307329/2022-4ALPR LCCB CNPq 406938/2024-5ALPR LCCB CNPq 408659/2024-6ALPR LCCB CNPq 445011/2023-8ALPR LCCB FAPEMIG (Minas Gerais State Foundation for Research Support) RED-00192-23Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology, and Innovation (FINEP-Funding Authority for Studies and Projects-and CNPq-National Council for Scientific and Technological Development) 01 06 0010.00Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology, and Innovation (FINEP-Funding Authority for Studies and Projects-and CNPq-National Council for Scientific and Technological Development) 01 06 0071.00Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology, and Innovation (FINEP-Funding Authority for Studies and Projects-and CNPq-National Council for Scientific and Technological Development) 01 06 0115.00Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology, and Innovation (FINEP-Funding Authority for Studies and Projects-and CNPq-National Council for Scientific and Technological Development) 01 06 0212.00Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology, and Innovation (FINEP-Funding Authority for Studies and Projects-and CNPq-National Council for Scientific and Technological Development) 01 06 0278.00Brazilian Ministry of Health (Department of Science and Technology) and the Ministry of Science, Technology, and Innovation (FINEP-Funding Authority for Studies and Projects-and CNPq-National Council for Scientific and Technological Development) 01 06 0300.00CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorl)SMB CNPq Research Productivity Fellowship 303656/2021-2
6 · The paper itself
Abstract
aimsDiabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status. MATERIAL AND
methodsWe analysed participants from the ELSA-Brasil cohort without diabetes at baseline and with valid endothelial function measurements. Microvascular endothelial function was assessed by peripheral arterial tonometry (PAT), using mean basal pulse amplitude (BPA), reflecting basal vascular tone and the PAT ratio, indicating vasodilatory capacity. Higher BPA and lower PAT ratio represent worse endothelial function. Sex-specific quartiles were analysed. Incident diabetes was assessed after a mean follow-up of 8.8 years (SD = 2.1). Cox proportional hazards models were adjusted for sex, age, education, physical activity, smoking, alcohol use and body mass index (BMI) or waist circumference.
resultsAmong 1268 participants (mean age 51 ± 8 years; 45% women; mean BMI 26.4 ± 4.4 kg/m
conclusionImpaired endothelial function at baseline was independently associated with incident diabetes in Brazilian adults, regardless of obesity. These findings highlight the role of vascular dysfunction in cardiometabolic disease development.
Indexed as
Diabetes MellitusDiabetes Mellitus, Type 2Diabetic AngiopathiesEndothelium, VascularAdultBody Mass IndexBrazilCohort StudiesFemaleHumansIncidenceMaleManometryMiddle AgedObesityRisk Factorscohort studiesdiabetes mellitusincidencevascular endothelium
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA-Brasil Cohort Study. · full record | OpenQuestion