Evidence map›Paper›PMID 42303154›Full record

ArticleJournal of lipid research2026

KRAS G12C and KRAS G12D respond to lipid metabolism in an allele-specific manner.

Neha Arora, Hong Liang, Walaa Kattan, Wantong Yao, Haoqiang Ying, Junchen Liu, Yong Zhou

Abstract read
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In one paragraph

Article in Journal of lipid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Neha AroraDepartment of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, Houston, Texas, USA.
Hong LiangDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Walaa KattanDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Wantong YaoDivision of Pathology-Lab Medicine Div, Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Haoqiang YingDivision of Basic Science Research, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Junchen LiuDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA.
Yong ZhouDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA; Program of Molecular and Translational Biology, Graduate School of Biological Sciences, M. D. Anderson Cancer Center and University of Texas Health Science Center, Houston, Texas, USA. Electronic address: yong.zhou@uth.tmc.edu.

Funding

Phosphatidylserine acyl chain remodeling regulates KRAS spatial distribution and function on the plasma membrane.R01GM138668 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHOU, YONG · 2021 to 2024
$1.3M
NIGMS NIH HHS R01 GM138668
6 · The paper itself

Abstract

KRAS mutated at hotspots G12, G13, and Q61 possess profound allele-specific oncogenesis. Signaling of KRAS mutants is mostly compartmentalized to the proteolipid nanoclusters on the plasma membrane (PM), illustrating critical roles of spatiotemporal organization in KRAS cancer signaling. The activated GTP-bound KRAS molecules, including the wild type and mutants, have been traditionally thought to favor similar lipids. We recently reported distinct lipid sensing capabilities of different KRAS mutants, especially with KRAS

Indexed as

AllelesLipid MetabolismProto-Oncogene Proteins p21(ras)1-Acylglycerophosphocholine O-AcyltransferaseAnimalsHumansMiceMutation1-Acylglycerophosphocholine O-AcyltransferaseKRAS protein, humanLpcat1 protein, humanProto-Oncogene Proteins p21(ras)acyl chainscancer biologyelectron microscopyKRASlysophosphatidylcholine acyltransferase 1nanoclusteringphosphatidylserinephospholipids

Identifiers

PMID42303154
PMCPMC13375922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.