ArticleAnimal bioscience2026
Genome-wide association studies of body weight, body conformation traits and coat color in Gamba sheep.
Article in Animal bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveElucidating the genetic architecture of body weight (BW), body conformation, and coat color (CC) is vital for the precision breeding of Gamba sheep, a unique high-altitude indigenous breed. Although previous studies focused on general plateau adaptation, the specific genetic factors regulating economic traits in this extreme-altitude population remain poorly understood.
methodsWe characterized six key phenotypic traits and conducted genome-wide association studies (GWAS) leveraging whole-genome resequencing data from 296 individuals. To ensure robustness, we systematically evaluated five statistical models. The SUPER model was selected for growth-related traits due to its superior power in balancing signal sensitivity and false-positive control, whereas the MLMM model was applied to the binary CC phenotype. Both models consistently yielded genomic inflation factors (λ) close to the theoretical expectation.
resultsPhenotypic analysis revealed distinct sexual dimorphism in growth determinants: cannon bone circumference was the primary driver influencing BW in rams, whereas body height and heart girth were predominant in ewes. The GWAS identified 82 genomewide significant SNPs, delineating a prominent novel genomic region on chromosome 5 associated with body height. Functional annotation highlighted PRKCE and SGIP1 as plausible positional candidate genes for growth characteristics, while SPIRE2 was pinpointed as a primary genomic driver regulating CC variation.
conclusionThese findings provide novel insights into the genetic blueprint governing growth and pigmentation in this unique livestock, offering precise molecular targets for future marker-assisted selection.
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