Evidence map›Paper›PMID 42302862›Full record

ArticleActa anaesthesiologica Scandinavica2026

Developing a Core Outcome Measurement Set for Adult ICU Patients, the CoreMS-ICU-A Protocol.

Maj-Brit Nørregaard Kjær, Camilla Rahbek Lysholm Bruun, Camilla Bekker Mortensen, Anna Schandl, Kimberley Haines, Kristin Hofsø, Fredrike Blokzijl, Anders Granholm, Morten Hylander Møller, Aske Tøgern and 44 more

Abstract read
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Article in Acta anaesthesiologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

54 authors.

Maj-Brit Nørregaard KjærDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-6536-0504
Camilla Rahbek Lysholm BruunDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0009-0004-6875-1369
Camilla Bekker MortensenDepartment of Anaesthesiology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0001-5202-3552
Anna SchandlDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3603-1912
Kimberley HainesDepartment of Physiotherapy, Western Health, Footscray, Australia.ORCID https://orcid.org/0000-0002-2882-1594
Kristin HofsøCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-5854-8461
Fredrike BlokzijlDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-4120-761X
Anders GranholmDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-5799-7655
Morten Hylander MøllerDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-6378-9673
Aske TøgernDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0009-0006-7858-4079
Bodil Steen RasmussenCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2190-145X
Lone Musaeus PoulsenCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-7030-3395
Thomas StrømCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.
Eva LaerknerDepartment of Anaesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark.ORCID https://orcid.org/0000-0001-6709-8055
Anne Craveiro BrøchnerCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-6453-6152
Trine HaberlandtDepartment of Anaesthesia and Intensive Care, Lillebælt Hospital, Kolding, Denmark.
Anne-Marie Gellert BunzelDepartment of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.ORCID https://orcid.org/0009-0002-9639-0623
Louise Stenbryggen HerløvDepartment of Anaesthesiology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0001-6638-1529
Anna HolmDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-2582-4984
Praleene SivapalanDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-0442-0032
Stine EstrupDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-1467-7085
Maria CronhjortCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-0444-8553
Jon Henrik LaakeCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-6157-5359
Carmen Andrea PfortmuellerCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-0326-2770
Marlies OstermannCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-9500-9080
Jade M ColeAdult Critical Care, University Hospital of Wales, Cardiff, UK.ORCID https://orcid.org/0009-0007-2833-727X
Matt P WiseCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-2763-4316
Anna WludarczykJagiellonian University Medical College - Centre for Intensive Care and Perioperative Medicine, Kraków, Poland.
Wojciech SzczeklikCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.
Tomas JovaišaFaculty of Medicine, Clinic of Anaesthesiology and Intensive Care, Vilnius University, Vilnius, Lithuania.
Maurizio CecconiDepartment of Biomedical Sciences, Humanitas University, Milan, Italy.ORCID https://orcid.org/0000-0002-4376-6538
Martin Ingi SigurdssonCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-7054-0844
Marek NalosCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-7977-9410
Johanna HästbackaCollaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-3613-7231
Marja MäkinenDepartment of Emergency Medicine and Services, Helsinki University and Helsinki University Hospital, Helsinki, Finland.ORCID https://orcid.org/0000-0002-2105-3107
Jacob DyeThe George Institute for Global Health, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-3469-2792
Naomi HammondThe George Institute for Global Health, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-6559-7747
Edward LittonIntensive Care Unit, Fiona Stanley Hospital, Robin Warren Drive, Murdoch, Western Australia, Australia.
Frederik KeusDepartment of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0003-1516-1475
Sheila Nainan MyatraDepartment of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India.ORCID https://orcid.org/0000-0001-6761-163X
Bharath Kumar Tirupakuzhi VijayaraghavanApollo Hospitals, Chennai, India.ORCID https://orcid.org/0000-0002-1801-0667
Kavita YadavThe George Institute for Global Health, New Delhi, India.
Balasubramanian VenkateshThe George Institute for Global Health, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-3234-5244
Ingrid EgerodDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-9576-4390
Rikke Faebo LarsenDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-3444-2774
Dale M NeedhamDivision of Pulmonary & Critical Care Medicine, and Department of Physical Medicine & Rehabilitation, School of Medicine, and School of Nursing, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-9538-0557
Louise RoseFaculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK.ORCID https://orcid.org/0000-0003-1700-3972
Bronwen ConnollyQueen's University Belfast, Belfast, UK.
Claudia SpiesDepartment of Anaesthesiology and Intensive Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Carol HodgsonDepartment of Critical Care, Melbourne Medical School, The University of Melbourne, Melbourne, Australia.
Daniel MunblitKing's College London, London, UK.ORCID https://orcid.org/0000-0001-9652-6856
Sarah GorstDepartment of Health Data Science, University of Liverpool, Liverpool, UK.
Anders PernerDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4668-0123
Marie O ColletDepartment of Intensive Care, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-8387-3960

Funding

Dagmar Marshalls FondDanmarks Frie Forskningsfond 10.46540/3165-00057BGrosserer Jakob Ehrenreich og Hustru Grete Ehrenreichs FondNovo Nordisk Fonden NNF23OC0085106Research Council of the Copenhagen University Hospital - RigshospitaletSavværksejer Jeppe Juhl og Hustru Ovita Juhls MindelegatSygeforsikringen "danmark" 2020-0320
6 · The paper itself

Abstract

backgroundCore outcome measurement sets (COMS) enhance the consistency and comparability of outcome reporting in clinical research. However, their effectiveness depends on the selection of valid, reliable, and feasible measurement instruments. Core outcome sets (COS) and COMS have been developed for specific intensive care unit (ICU) patient subgroups. The aim of this study is to establish a standardised approach to outcome measurement and operationalisation for adults acutely admitted to the ICU who are participating in clinical trials and other clinical research.

methodsThis protocol describes the development of a COMS for adults acutely admitted to the ICU, the CoreMS-ICU, consisting of six core outcomes: survival, free of life support, free of delirium, out of hospital, health-related quality of life, and cognitive function. We will follow the Consensus-based Standards for the Selection of Health Measurement Instruments guideline and report according to the Core Outcome Set-STAndardised Protocol Items guideline. The development of the CoreMS-ICU will follow five predefined steps: (1) conceptual considerations for the six core outcomes; (2) systematic searches for outcome measurement instruments, including consideration of existing COMS; (3) quality assessment of relevant outcome measurement instruments; (4) consensus-based selection of outcome measurement instruments; and (5) recommendations and guidance on how to operationalise and report the measurement of the six core outcomes. We will involve research panels consisting of key stakeholders: patients, family members, healthcare professionals, and researchers in steps 1 and 4.

conclusionsWe aim to develop a COMS for adults acutely admitted to ICU patients to facilitate the consistent use of outcomes in trials and enhance the translation of research findings into clinical practice.

Indexed as

Critical CareIntensive Care UnitsOutcome Assessment, Health CareAdultHumansQuality of LifeResearch Designclinical researchcore outcome measurement setpatient‐centred outcomesstakeholder involvement

Identifiers

PMID42302862
PMCPMC13271819

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.