Evidence map›Paper›PMID 42302793›Full record

ArticleCell reports. Medicine2026

Sustained mucosal delivery of SAMT-247 via an intravaginal ring reduces the risk of SIV

Mohammad Arif Rahman, Emmanuel K Woode, John A Moss, Massimiliano Bissa, Manjula Gunawardana, Anna Gutowska, Luca Schifanella, Isabela Silva de Castro, Sophia Brown, James D Stamos and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Mohammad Arif RahmanAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: mohammadarif.rahman@nih.gov.
Emmanuel K WoodeAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
John A MossOak Crest Institute of Science, Monrovia, CA, USA.
Massimiliano BissaAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Manjula GunawardanaOak Crest Institute of Science, Monrovia, CA, USA.
Anna GutowskaAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Luca SchifanellaAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Isabela Silva de CastroAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sophia BrownAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
James D StamosAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sarkis SarkisAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Marco RobelloSynthetic Bioactive Molecules Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Amalia E CastonguayOak Crest Institute of Science, Monrovia, CA, USA.
Irina ButkyavicheneOak Crest Institute of Science, Monrovia, CA, USA.
Cynthia A Pise-MasisonAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Hyoyoung Choo-WosobaOffice of Collaborative Biostatistics, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Melvin DosterAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Aian Neil AlilinLaboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA.
Kristin Elizabeth KilloranLaboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA.
Joshua KramerLaboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA.
Matthew W BreedLaboratory Animal Medicine, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Bethesda, MD, USA; Clemson University, Clemson, SC, USA.
Timothy CardozoNew York University Grossman School of Medicine, NYU Langone Health, New York, NY, USA.
Daniel H AppellaSynthetic Bioactive Molecules Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Marc M BaumOak Crest Institute of Science, Monrovia, CA, USA.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: franchig@mail.nih.gov.

Funding

NIH HHS HHSN272201800003C
6 · The paper itself

Abstract

We assess the combined effect of sustained mucosal delivery of the anti-HIV small molecule S-acyl-2-mercaptobenzamide thioester 247 (SAMT-247) via an intravaginal ring (IVR) and ΔV1DNA/ALVAC-SIV/ΔV1gp120/alum (ΔV1-SIV) immunization in female macaques. The combined approach reduces the risk of vaginal SIV

Indexed as

BenzamidesSAIDS VaccinesSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusSulfhydryl CompoundsAdministration, IntravaginalAnimalsFemaleImmunity, MucosalKiller Cells, NaturalMacaca mulattaMucous MembraneVaccinationVaginaBenzamidesSAIDS VaccinesSulfhydryl Compoundsdendritic cellsHIV/SIV vaccineimmunomodulationinfiltrating monocytesinnate lymphoid cellsmucosal immunitySAMT-247SIVmac251V2-specific ADCCvaccine-induced immunity

Identifiers

PMID42302793
PMCPMC13400162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.