ArticleJournal of veterinary internal medicine2026
Heart rate variability in dogs with brachycephalic obstructive airway syndrome evaluated during wakefulness and sleep.
Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBrachycephalic obstructive airway syndrome (BOAS) affects the upper airways of brachycephalic dogs and might alter heart rate variability (HRV). HYPOTHESIS/
objectivesThis study aimed to evaluate HRV in dogs with BOAS during wakefulness and sleep. ANIMALS: Forty-six client-owned dogs: 34 brachycephalic (with and without BOAS) and 12 non-brachycephalic controls.
methodsA prospective cross-sectional study utilizing 24-h Holter monitoring and segments recorded during wakefulness and sleep. The evaluated variables included heart rate, mean RR interval, the longest sinus pause, and HRV indices calculated over 24 h, as well as during segments of wakefulness and sleep: corrected standard deviation of NN intervals (cSDNN), corrected root mean square of successive differences (cRMSSD), the vagal tone index (VVTI), and Poincaré plot analysis.
resultsIn the 24-h Holter analysis, BOAS dogs showed significantly higher values than controls, particularly in cSDNN (0.365 [IQR: 0.306-0.465] vs 0.246 [IQR: 0.208-0.359] ms, P = .0058) and cRMSSD (0.476 [IQR: 0.409-0.599] vs 0.312 [IQR: 0.259-0.462] ms, P = .0119). Sleep was associated with higher cSDNN, cRMSSD, and VVTI in all groups (StateSleep estimates: 0.105 [95% CI, 0.062-0.149], 0.426 [95% CI, 0.264-0.588], and 1.758 [95% CI, 1.378-2.139], respectively; all P < .001), with no significant group-by-state interaction for these variables. Presence of BOAS was moderately correlated with the longest sinus pause (r = 0.4197, P = .0023), cSDNN (r = 0.4600, P = .0006), and cRMSSD (r = 0.4214, P = .0018). CONCLUSIONS AND CLINICAL IMPORTANCE: The presence of BOAS influences autonomic modulation more than the dogs' craniofacial conformation. Differences in HRV were more pronounced in awake dogs, likely due to chronic respiratory alterations and intermittent hypoxia.
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