Parathyroid Carcinoma Mimicking a Parathyroid Adenoma on [ 18 F]F-Choline-PET With Occult Metastases.

Carola M Bregenzer, Roman Trepp, Florian Dammann, Reto M Kaderli, Aziz Chouchane, Robert Seifert

Abstract readCase Reports

In one paragraph

Article in Clinical nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

6 authors.

Carola M BregenzerDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0009-0007-3755-4807

Roman TreppDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.

Florian DammannDepartment of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Reto M KaderliVisceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern.

Aziz ChouchaneInstitute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland.

Robert SeifertDepartment of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 80-year-old man with hypercalcemia and hyperparathyroidism was suspected of having a parathyroid adenoma, which was localized on [ 18 F]F-choline-PET/CT. Still, after surgical removal of the suspected adenoma with an intraoperative parathyroid hormone decrease of >50%, severe hypercalcemia recurred quickly. A repeated [ 18 F]F-choline-PET/CT raised suspicion of a single contralateral parathyroid adenoma or multiglandular disease. Given the inconclusive findings, a histological reassessment of the suspected parathyroid adenoma showed the presence of a singular vessel invasion, which alerted the diagnosis to parathyroid carcinoma. An additionally performed [ 18 F]FDG-PET/CT revealed a liver lesion and MRI confirmed multiple liver metastases, which could not be seen on [ 18 F]F-choline-PET/CT.

Indexed as

AdenomaCholineParathyroid NeoplasmsPositron-Emission TomographyPositron Emission Tomography Computed TomographyAged, 80 and overDiagnosis, DifferentialHumansMaleNeoplasm MetastasisCholineparathyroid adenomaparathyroid carcinoma

Identifiers

PMID42302384

DOI10.1097/RLU.0000000000006555

PMCPMC13317897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.