Considerations for the selection and phenotyping of mouse models for the study of Alzheimer's disease.

Sevda Boyanova, Loukia Katsouri, Julija Krupic, Kaitlyn Hair, Szu-Han Wang, Frances K Wiseman

Abstract readReview

In one paragraph

Review in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sevda BoyanovaUK Dementia Research Institute at University College London, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.

Loukia KatsouriSainsbury Wellcome Centre, University College London, London W1T 4JG, UK.

Julija KrupicUK Dementia Research Institute at University College London, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.

Kaitlyn HairEvidence for Policy & Practice Information Centre, University College London Social Science Research Unit, University College London, London WC1H 0NU, UK.

Szu-Han WangInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh EH16 4SB, UK.

Frances K WisemanUK Dementia Research Institute at University College London, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK. Electronic address: f.wiseman@ucl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

All models are incomplete and must balance the need for experimental efficiency with the complexity of the natural world. To select and use models for the study of human disease, it is critical to understand what is of fundamental scientific importance and which limitations are thus of greatest concern. Here, we highlight key considerations for the design of research studies using mouse models of aspects of Alzheimer's disease for both mechanistic and proof-of-principle intervention studies. This primer considers mouse model choice, including the strengths and limitations of genetically altered, pathological aggregates injection, and human iPSC-chimera systems. We also review key principles of experimental design, husbandry, and technical considerations for the phenotyping of clinically disease-relevant features, with a focus on behavior and cognition.

Indexed as

BehaviorModel OrganismsNeuroscienceNMGN Focused CollectionSpecial Issue

Identifiers

PMID42301821

DOI10.1016/j.xpro.2026.104633

PMCPMC13284463

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.