ArticleAnnals of Indian Academy of Neurology2026
A Study on the Spectrum of Autonomic Dysfunction in Primary Central Nervous System Demyelinating Disorders in a Tertiary Care Center from Eastern India.
Article in Annals of Indian Academy of Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPrimary central nervous system (CNS) demyelinating disorders such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and seronegative longitudinally extensive transverse myelitis (LETM) frequently affect the autonomic nervous system (ANS). Comprehensive data across genitourinary, sudomotor, gastrointestinal, and sexual domains remain limited, especially in Southeast Asian populations. This study aimed to explore the spectrum of autonomic dysfunction in patients with primary CNS demyelination.
methodsIn this cross-sectional observational study, 90 patients aged 18-60 years with confirmed diagnoses of MS, NMOSD, MOGAD, or LETM were enrolled after applying strict exclusion criteria. Autonomic function was assessed through clinical history, bedside examination, and validated questionnaires, including Composite Autonomic Symptom Score-31 (COMPASS-31), International Index of Erectile Function (IIEF), and Female Sexual Function Index (FSFI).
resultsOf the 90 patients, significant autonomic involvement (COMPASS > 13.6) was present in 42.2%, most pronounced in LETM (69.2%). Urinary retention with overflow incontinence was common. Erectile dysfunction affected 96.8% of men, with severe dysfunction in 41.7% of MS, 66.7% of NMOSD, and 75% of LETM. Female sexual dysfunction was documented in 29.7%-41.7% across subgroups. Orthostatic intolerance, gastrointestinal abnormalities, and pupillomotor disturbances were frequent. LETM patients showed the worst autonomic profile overall.
conclusionsAutonomic dysfunction is highly prevalent in CNS demyelination, with urinary and sexual dysfunction particularly burdensome in NMOSD and LETM. Parasympathetic dysfunction predominated in MS, whereas sympathetic impairment was equivocally evident in MS and NMOSD. Comprehensive screening of autonomic domains should be integrated into routine care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.