Evidence map›Paper›PMID 42301602›Full record

ArticleSpine deformity2026

Incidence and outcomes of spinopelvic fixation loosening following adult spinal deformity surgery.

John D Arena, Yohannes Ghenbot, Mert Marcel Dagli, Joshua L Golubovsky, Ben Gu, Addison Quinones, Dominick Macaluso, Neil R Malhotra, Zarina S Ali, Brendan F Judy and 5 more

Abstract read
In one paragraph

Article in Spine deformity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

John D ArenaDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4322-4472
Yohannes GhenbotDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Mert Marcel DagliDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5201-6720
Joshua L GolubovskyDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ben GuDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Addison QuinonesDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dominick MacalusoDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3924-6687
Neil R MalhotraDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zarina S AliDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9048-0487
Brendan F JudyDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4981-1408
Jang W YoonDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
William C WelchDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1665-7985
Vincent ArletDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
John H ShinDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7490-8108
Ali K OzturkDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ali.ozturk@pennmedicine.upenn.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo identify the incidence and clinical outcomes of spinopelvic fixation loosening following surgical correction of adult spinal deformity (ASD).

methodsA single-institution retrospective cohort of 152 consecutive patients meeting inclusion criteria who underwent long-segment fusion with pelvic fixation for correction of ASD was reviewed. Pelvic screws were assessed on follow-up post-operative standing radiographs for evidence of loosening. Surgical revision of spinal instrumentation served as the primary outcome. PROMIS Pain Interference and Physical Function T-Scores were assessed as secondary outcomes among the subset of cases (n = 92) with available scores.

resultsPelvic screw loosening was appreciated in 25 cases (16.4%) with initial evidence of loosening identified a median 1.1 years (Q1: 0.8, Q3: 2.5) following surgery. Loosening of pelvic screws (OR 3.0, 95% CI 1.2-7.3, p = .017) was associated with significantly increased odds of eventual instrumentation revision surgery, including specifically surgical revision of spinopelvic fixation (OR 5.5, 95% CI 1.6-18.5, p = .006). 4 of 26 cases (15%) with S2-Alar-Iliac (S2AI) screws required revision surgery compared to 37 of 126 cases (29%) without S2AI screws. PROMIS T-Scores were significantly worse for patients requiring instrumentation revision surgery but did not differ between cases with and without loosening.

conclusionLoosening of spinopelvic fixation occurs frequently following correction of ASD and can develop years following surgery. While distal construct screw loosening may be appreciated incidentally at follow-up, loosening of pelvic screws was associated with significantly increased odds of eventual instrumentation revision surgery.

Indexed as

Bone ScrewsEquipment FailurePostoperative ComplicationsProsthesis FailureSpinal CurvaturesSpinal FusionAdultAgedFemaleHumansIncidenceMaleMiddle AgedRadiographyReoperationRetrospective StudiesIliac screwKyphosisPelvic fixationS2AI screwScoliosisSpine deformity

Identifiers

PMID42301602
PMCPMC13553674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.