ArticleMetabolomics : Official journal of the Metabolomic Society2026
Metabolomic characterization and temporal dynamics of Burkholderia cepacia for polyhydroxyalkanoates production from oleic acid.
Article in Metabolomics : Official journal of the Metabolomic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolyhydroxyalkanoates (PHA) have become biodegradable alternatives for replacing chemical polymers. However, high production costs remain the primary obstacle to the commercial application of this bioprocess, prompting the use of metabolic engineering approaches to optimize PHA quality and increase productivity.
objectivesThis study aimed to identify the endometabolome at different stages during a dynamic fermentation of Burkholderia cepaciausing oleic acid as the carbon source. METHODOLOGY: Untargeted metabolomic analysis was conducted using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) techniques. Univariate (UVA) and multivariate (MVA) statistical analyses were performed to determine significant differences between metabolomic profiles.
resultsA total of 24 significant metabolites were identified through GC-MS analysis and 223 through LC-MS, highlighting organic compounds and lipids associated with pathways such as ß-oxidation, the tricarboxylic acid cycle, and the pentose phosphate pathway. Acetyl-CoA emerged as a critical common intermediate in both central biosynthetic and PHA-producing pathways.
conclusionAcetyl-CoA plays a fundamental role in the complex regulatory system activated by nutrient fluctuations in the culture medium, suggesting that the microorganism undergoes metabolic reorganization to optimize carbon source utilization for cellular maintenance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.