ArticleSurgical endoscopy2026
Long-term outcomes after non-curative endoscopic submucosal dissection for undifferentiated early gastric cancer: a multicenter retrospective study.
Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundThe prognosis of non-curative endoscopic submucosal dissection (ESD) for undifferentiated-type early gastric cancer (UD-EGC) remains unclear. This study aimed to identify risk factors for residual tumor, lymph node metastasis (LNM), and recurrence after non-curative ESD, and to define a potential low-risk subgroup suitable for active surveillance rather than additional surgery.
methodsThis retrospective multicenter study included patients with non-curative ESD for UD-EGC from five institutions between 2017 and 2021. Patients were categorized into an additional surgery group or an observation group according to subsequent management. Clinicopathologic characteristics and survival outcomes were compared.
resultsNinety-nine patients were analyzed, including 44 in the observation group and 55 in the additional surgery group. The median follow-up duration was 64 months. Six patients undergoing surveillance experienced recurrence within 12.0 to 37.3 months after ESD. Fourteen patients in the additional surgery group showed residual tumor or LNM. Vertical margin involvement independently predicted recurrence in the observation group, while ulceration and vertical margin involvement were independent predictors of residual tumor or LNM in surgical specimens or recurrence. Overall and disease-free survival were worse in the observation group. Disease-free survival in the observation group was associated with depth of invasion, lymphatic invasion, venous invasion, and resection margin status. Lesions with negative resection margins and no lymphovascular invasion meeting either (1) pT1a, UL0, > 2 cm, or (2) pT1a, UL1, ≤ 3 cm demonstrated excellent long-term outcomes without recurrence.
conclusionsAdditional surgery remains standard after non-curative ESD for UD-EGC. However, a carefully selected low-risk subgroup may be appropriate candidates for close surveillance instead of further surgical intervention.
Indexed as
Identifiers
42301470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.