Evidence map›Paper›PMID 42301424›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

CXCR4-targeted PET/CT in early systemic sclerosis-associated interstitial lung disease: a prospective proof-of-concept study of in vivo inflammatory activity.

Michael Gernert, Marc Schmalzing, Hannah Labinsky, Yingjun Zhi, Patrick-Pascal Strunz, Matthias Fröhlich, Philipp E Hartrampf, Andreas K Buck, Rudolf A Werner, Sebastian E Serfling

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael GernertDepartment of Internal Medicine 2, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany.
Marc SchmalzingDepartment of Internal Medicine 2, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany.
Hannah LabinskyDepartment of Internal Medicine 2, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany.
Yingjun ZhiDepartment of Otorhinolaryngology, Head and Neck Surgery, University Hospital Würzburg, Würzburg, Germany.
Patrick-Pascal StrunzDepartment of Internal Medicine 2, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany.
Matthias FröhlichDepartment of Internal Medicine 2, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, Germany.
Philipp E HartrampfDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Rudolf A WernerThe Russell H Morgan, Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sebastian E SerflingDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. serfling_s1@ukw.de.ORCID 0009-0001-5740-0537

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDistinguishing active inflammatory or remodeling-associated processes from irreversible fibrosis in systemic sclerosis remains challenging using conventional imaging modalities. The tracer [

methodsThis prospective cohort study included patients with early SSc (disease duration ≤ 5 years) and preexisting interstitial lung disease. All patients underwent [

resultsTwelve patients with SSc were included. The highest [

conclusionThese findings provide proof-of-concept evidence that CXCR4-targeted PET/CT may visualize biologically active inflammatory and/or remodeling processes in early-stage SSc-ILD.

Indexed as

Lung Diseases, InterstitialPeptides, CyclicPositron Emission Tomography Computed TomographyReceptors, CXCR4Scleroderma, SystemicAgedCoordination ComplexesFemaleGallium RadioisotopesHumansInflammationMaleMiddle AgedProof of Concept StudyProspective Studies68Ga-pentixaforCoordination ComplexesCXCR4 protein, humanGallium RadioisotopesPeptides, CyclicReceptors, CXCR4[68Ga]PentixaforConnective tissue diseaseC-X-C motif chemokine receptor 4Interstitial lung diseasePositron emission tomographySystemic sclerosis

Identifiers

PMID42301424
PMCPMC13526056

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.