Evidence map›Paper›PMID 42301421›Full record

ArticleArchives of microbiology2026

Antibiotic exposure and recovery of persister states influence virulence phenotypes in Pseudomonas aeruginosa.

Waleska Stephanie da Cruz Nizer, Carlos Eduardo Dias Igídio, Estela Mafra Ribeiro, Allanis Cristiny Oliveira Andrade, Samantha Neves de Oliveira, Mauro Martins Teixeira, Daniele da Glória de Souza, Caio Tavares Fagundes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Waleska Stephanie da Cruz NizerHost-Microorganism Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. waleskaob@gmail.com.ORCID http://orcid.org/0000-0002-5134-719X
Carlos Eduardo Dias IgídioHost-Microorganism Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-7480-5405
Estela Mafra RibeiroHost-Microorganism Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0009-0002-9347-1946
Allanis Cristiny Oliveira AndradeHost-Microorganism Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Samantha Neves de OliveiraHost-Microorganism Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0003-1519-0970
Mauro Martins TeixeiraDrug Research and Development Center, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-6944-3008
Daniele da Glória de SouzaHost-Microorganism Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-7478-5934
Caio Tavares FagundesHost-Microorganism Interaction Laboratory, Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. caio.fagundes@gmail.com.ORCID http://orcid.org/0000-0002-6747-5233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenicity of P. aeruginosa is not only mediated by its resistance mechanisms but also by its ability to form persister cells. The persister state is a transient condition in which cells retain a dormant, non- or slow-growing state during exposure to stressors, such as high doses of bactericidal antibiotics, but can resume growth once the stress is removed. In this study, we investigated in vitro the virulence phenotype and stress-induced modulation of persisters in P. aeruginosa PA14 exposed to 30 × the minimum inhibitory concentration (MIC) of imipenem (60 µg/mL) or ciprofloxacin (3.75 µg/mL). Using a biphasic killing assay, we detected persisters with survival levels of 4.8 and 3.4 log

Indexed as

Anti-Bacterial AgentsPseudomonas aeruginosaBiofilmsCiprofloxacinHydrogen PeroxideImipenemMicrobial Sensitivity TestsMicrobial ViabilityPhagocytosisPhenotypeVirulenceAnti-Bacterial AgentsCiprofloxacinHydrogen PeroxideImipenemBiofilmsFluoroquinoloneGram-negative bacteriaPersistencePseudomonas aeruginosaβ-lactams

Identifiers

PMID42301421
PMCPMC13272224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.