Evidence map›Paper›PMID 42301349›Full record

ArticleArchives of microbiology2026

Engineering of glycerol-derived aldolase pathway improves D-allulose synthesis in a glucose-glycerol dual-carbon system.

Yifan Tu, Jing Lv, Mulan Wang, Tanxiang Huang, Lei Hu, Chen Liang, Xiyao Cheng, Jidong Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yifan Tu *College of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China.
Jing Lv *College of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China.
Mulan WangCollege of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China.
Tanxiang HuangCollege of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China.
Lei HuCollege of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China.
Chen LiangCollege of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China.
Xiyao ChengCollege of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China. xiyaocheng@gxu.edu.cn.
Jidong LiuCollege of Light Industry and Food Engineering, Guangxi University, 100 Daxue East Road, Nanning, 530004, Guangxi, China. liujd@gxu.edu.cn.

Funding

the Innovation Project of Guangxi Graduate Education YCSW2025127the Natural Science Foundation of Guangxi Province 2025GXNSFAA069706
6 · The paper itself

Abstract

D-allulose is a rare sugar with multiple physiological functions and industrial applications. Efficient microbial production of D-allulose requires appropriate carbon allocation between cell growth and product formation. In this study, an engineered Escherichia coli BL21(DE3) strain was constructed for D-allulose biosynthesis using a glucose-glycerol co-utilization strategy. First, we established a phosphorylation-driven D-allulose pathway, achieving a titer of 1.43 g/L of D-allulose. However, knocking out the pfkA gene impaired cell growth, and the biomass OD

Indexed as

Aldehyde-LyasesEscherichia coliFructoseGlucoseGlycerolMetabolic EngineeringBiomassCarbonEscherichia coli ProteinsFermentationAldehyde-LyasesCarbonEscherichia coli ProteinsFructoseGlucoseGlycerolpsicoserhamnulose-1-phosphate adolaseD-alluloseEscherichia coliMicrobial fermentationMixed carbon sources

Identifiers

PMID42301349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.