Evidence map›Paper›PMID 42301284›Full record

ArticleAbdominal radiology (New York)2026

Discriminating papillary renal cell carcinoma from metanephric adenoma: a quantitative contrast-enhanced CT-based analysis.

Jie Zhan, Ting Zhang, Yuexi Wu, Jiaxin Huang, Zitao Huang, Jing Chen, Wanli Zhang, Jing Yan, Wansong Wang, Yanqing Yu and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie ZhanGuangzhou First People's Hospital, Guangzhou, China.
Ting ZhangGuangzhou Zengcheng District Hospital of Traditional Chinese Medicine, Guangzhou, China.
Yuexi WuSchool of Medicine, The Second Affiliated Hospital, South China University of Technology, Guangzhou, China.
Jiaxin HuangSchool of Medicine, The Second Affiliated Hospital, South China University of Technology, Guangzhou, China.
Zitao HuangGuangzhou First People's Hospital, Guangzhou, China.
Jing ChenYichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Wanli ZhangGuangzhou First People's Hospital, Guangzhou, China.
Jing YanThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wansong WangDepartment of Rehabilitation Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Yanqing YuDepartment of Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Shengsheng LaiSchool of Medical Equipment, Guangdong Food and Drug Vocational College, Guangzhou, China. laiss@gdyzy.edu.cn.
Ruimeng YangGuangzhou First People's Hospital, Guangzhou, China. eyruimengyang@scut.edu.cn.

Funding

2025 Research Project of Guangdong Health Information Network Association MS-202509-0047Clinical Research Hongmian Project of Guangzhou First People's Hospital HM2025038Medical Science and Technology Research Project of Guangdong Province A2024637National Natural Science Foundation of China 62262029National Natural Science Foundation of China 82371908Natural Science Foundation of Guangdong Province 2024A1515012177Natural Science Foundation of Jiangxi Province 2024A1515012177
6 · The paper itself

Abstract

backgroundMetanephric adenoma (MA) and papillary renal cell carcinoma (pRCC) demonstrate overlapping hypovascular appearances on contrast-enhanced computed tomography (CECT), yet reliable quantitative imaging criteria for their preoperative differentiation are still lacking. This study aimed to evaluate the diagnostic value of quantitative parameters derived from multiphasic CECT for differentiating MA from pRCC.

methodsNinety-three patients with pathologically confirmed renal tumors (MA, n = 31; pRCC, n = 62) were retrospectively included. CT attenuation values of renal tumors and the ipsilateral renal cortex were measured on unenhanced (UP), corticomedullary (CMP), and nephrographic (NP) phases in all 93 patients, and on the excretory (EP) phase in 84 patients (26 MA, 58 pRCC) as EP images were unavailable in the remaining nine patients. Multiple quantitative parameters were derived. After standardization, univariable and multivariable logistic regression analyses were performed to identify independent predictors, and several multivariable diagnostic models were constructed and compared.

resultsUnivariable analysis demonstrated significant differences between pRCC and MA in age, sex, and multiple quantitative parameters derived from the NP and EP. Among these parameters, the absolute tumor enhancement difference between the excretory and unenhanced phases (EP

conclusionQuantitative CECT parameters, particularly those derived from the delayed phases (nephrographic and excretory)-including absolute tumor attenuation values, absolute tumor enhancement differences, absolute tumor-to-cortex ratios, and relative tumor-to-cortex ratios-demonstrate substantial potential for the noninvasive differentiation between MA and pRCC.

Indexed as

Computed tomographyDifferential diagnosisMetanephric adenomaPapillary renal cell carcinoma

Identifiers

PMID42301284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.