Evidence map›Paper›PMID 42301175›Full record

ArticleJACC. Case reports2026

Congenital Heart Disease in a Paralympic Athlete With Klinefelter Syndrome.

Francisco B Alexandrino, Michael Villalonga, Nandini Mehra, Tara Karamlou, Joanna Ghobrial, Margaret Fuchs, Tamanna K Singh

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francisco B AlexandrinoDepartment of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Michael VillalongaDepartment of Internal Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Nandini MehraDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Tara KaramlouDepartment of Cardiac Surgery, Akron Children's Hospital, Akron, Ohio, USA.
Joanna GhobrialDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Margaret FuchsDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Tamanna K SinghDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA. Electronic address: SINGHT2@ccf.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSinus venosus atrial septal defects with partial anomalous pulmonary venous return (PAPVR) are rare congenital abnormalities. CASE SUMMARY: A 26-year-old competitive swimmer with Klinefelter syndrome was referred for evaluation after echocardiography revealed right-sided chamber dilation. Multimodality imaging confirmed sinus venosus atrial septal defects with PAPVR of the right upper and middle pulmonary veins draining into the superior vena cava (pulmonary/systemic flow ratio = 1.8). He underwent successful pericardial-patch closure and venous baffling to the left atrium. At 1 year, imaging showed intact repair and unobstructed venous flow. He resumed competitive swimming and remains asymptomatic while training for the 2028 Paralympic Games. DISCUSSION: This case illustrates preserved exercise capacity and full postoperative recovery in an athlete with atrial septal defect-PAPVR. TAKE-HOME MESSAGES: Athletes with congenital heart disease and disability can safely pursue competitive sports. In atrial septal defect, preserved exercise capacity does not exclude hemodynamically significant congenital heart disease.

Indexed as

atrial septal defectcongenital heart diseaseexercise capapulmonary/systemic flow ratiocityKlinefelter syndromeParalympic

Identifiers

PMID42301175
PMCPMC13379820

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