Evidence map›Paper›PMID 42300933›Full record

ArticleJournal of materials chemistry. B2026

Designing polymer-peptide conjugates to target dipeptide repeat aggregates implicated in amyotrophic lateral sclerosis.

Vincent P Gray, Zixian Cui, Mackenzie Klepsig, Rachel A Letteri

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vincent P GrayDepartment of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA. rl2qm@virginia.edu.
Zixian CuiDepartment of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA. rl2qm@virginia.edu.
Mackenzie KlepsigDepartment of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA. rl2qm@virginia.edu.
Rachel A LetteriDepartment of Chemical Engineering, University of Virginia, Charlottesville, Virginia 22903, USA. rl2qm@virginia.edu.ORCID http://orcid.org/0000-0002-2919-203X

Funding

Biotechnology Training ProgramT32GM136615 · NIGMS · UNIVERSITY OF VIRGINIA · PI Silvia Salinas Blemker, Kimberly A. Kelly · 2020 to 2026
$3.4M
Optimizing therapeutic peptide presentation within polymersR35GM147424 · NIGMS · UNIVERSITY OF VIRGINIA · PI Rachel Letteri · 2022 to 2026
$1.8M
NIGMS NIH HHS R35 GM147424NIGMS NIH HHS T32 GM136615
6 · The paper itself

Abstract

Toxic dipeptide repeats such as the aggregating glycine-alanine (GA)

Indexed as

Amyotrophic Lateral SclerosisDipeptidesPeptidesPolymersHumansProtein AggregatesDipeptidesPeptidesPolymersProtein Aggregates

Identifiers

PMID42300933
PMCPMC13267777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.