ArticleJournal of medicinal chemistry2026
Mechanistic Exploration of Half-Sandwich Iridium(III) Anticancer Compounds through Integrated Cellular, Proteomic, and In Vivo Analyses.
Pavel Štarha, Jaroslava Friedecká, Renata Héžová, Ondřej Bárta, Rea Jarošová, Josef Mašek, Ivan Nemec, David Milde, Adam Novobilský, Ladislav Novotný and 5 more
Abstract read
In one paragraphArticle in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Pavel ŠtarhaDepartment of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic.ORCID 0000-0003-0422-045X Jaroslava FriedeckáLaboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, and Faculty of Science, Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.ORCID 0000-0001-8030-6736 Renata HéžováDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
Ondřej BártaDepartment of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic.ORCID 0000-0002-0982-399X Rea JarošováDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
Josef MašekDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
Ivan NemecDepartment of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic.ORCID 0000-0003-3231-7849 David MildeDepartment of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic.
Adam NovobilskýDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
Ladislav NovotnýDepartment of Veterinary Sciences, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences, Kamýcká 129, 16500 Prague, Czech Republic.ORCID 0000-0002-2222-1061 Jaroslav OndrušDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
Slavomíra ŠterbinskáDepartment of Inorganic Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146 Olomouc, Czech Republic.ORCID 0009-0000-3766-6015 Nicol StrakováDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.
René LenobelLaboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, and Faculty of Science, Palacký University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic.ORCID 0000-0001-7387-0056 Jan HošekDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 296/70, 62100 Brno, Czech Republic.ORCID 0000-0003-0975-1671 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
New half-sandwich iridium(III) compounds [Ir(η
Indexed as
Antineoplastic AgentsCoordination ComplexesIridiumAnimalsApoptosisCell Line, TumorHumansMiceOxidative StressProteomicsAntineoplastic AgentsCoordination ComplexesIridium
Identifiers
PMID42300762
PMCPMC13370875
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