Evidence map›Paper›PMID 42300739›Full record

ArticleMicrobiology spectrum2026

MexXY-OprM efflux pump mediates resistance to odilorhabdins in

Emilie Racine, Lucile Pantel, Kelly Maurent, Hazel L S Fuchs, Matthieu Sarciaux, Jessica Houard, Bettina Hinkelmann, Marie Attwood, Cédric Muller, Sophie Guénard and 5 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Emilie RacineNosopharm, Nîmes, France.ORCID 0000-0002-4265-9669
Lucile PantelNosopharm, Nîmes, France.
Kelly MaurentNosopharm, Nîmes, France.
Hazel L S FuchsDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID 0000-0003-3283-001X
Matthieu SarciauxNosopharm, Nîmes, France.
Jessica HouardNosopharm, Nîmes, France.
Bettina HinkelmannDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Marie AttwoodBristol Centre for Antimicrobial Research and Evaluation (BCARE), Infection Sciences, Southmead Hospital, Bristol, United Kingdom.ORCID 0000-0003-1047-2098
Cédric MullerSmaltis, Bioinnovation, Rue Charles Bried, Besançon, France.
Sophie GuénardSmaltis, Bioinnovation, Rue Charles Bried, Besançon, France.
Alan NoelBristol Centre for Antimicrobial Research and Evaluation (BCARE), Infection Sciences, Southmead Hospital, Bristol, United Kingdom.
Alasdair MacGowanBristol Centre for Antimicrobial Research and Evaluation (BCARE), Infection Sciences, Southmead Hospital, Bristol, United Kingdom.ORCID 0000-0002-6720-5268
Alain GivaudanDGIMI, Univ Montpellier, INRAE, Montpellier, France.ORCID 0000-0002-3901-5133
Mark BrönstrupDepartment of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID 0000-0002-8971-7045
Maxime GualtieriNosopharm, Nîmes, France.ORCID 0000-0001-6590-2468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The urgent need for new antibiotic classes to treat infections caused by multidrug-resistant gram-negative pathogens has driven interest in odilorhabdins (ODLs), a novel class of cationic antimicrobial peptides that target the bacterial ribosome. NOSO-502, the first clinical candidate in this family, exhibits potent activity against multidrug-resistant

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial Outer Membrane ProteinsBacterial ProteinsMembrane Transport ProteinsPseudomonas aeruginosaDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacterial Outer Membrane ProteinsBacterial ProteinsMembrane Transport ProteinsMexXY protein, Pseudomonas aeruginosaOprM protein, Pseudomonas aeruginosaantimicrobial resistanceefflux pump-mediated resistanceMexXY-OprModilorhabdinsPseudomonas aeruginosaribosome-targeting antibiotics

Identifiers

PMID42300739
PMCPMC13340244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.