ArticleJournal of Alzheimer's disease : JAD2026
Traumatic brain injury and late-life Alzheimer's disease neuropathology: Quantitative investigation in the Adult Changes in Thought study.
Enna Selmanovic, Laura E Gibbons, Rebecca D Folkerth, C Dirk Keene, Amber Nolan, Paul Crane, Nadia Postupna, Cecilia S Lee, Caitlin S Latimer, Jeanelle Ariza-Torres and 2 more
Abstract read
In one paragraphArticle in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Enna SelmanovicNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5350-4566 Laura E GibbonsDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0001-5054-2543 Rebecca D FolkerthDepartment of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3858-7949 C Dirk KeeneDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Amber NolanDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Paul CraneDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Nadia PostupnaDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Cecilia S LeeJohn F. Hardesty MD Department of Ophthalmology and Visual Sciences, Washington University in St Louis, St Louis, MO, USA.
Caitlin S LatimerDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Jeanelle Ariza-TorresDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Patrick R HofNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kristen Dams-O'ConnorNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-2506-0216 Funding
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4MAging eyes and aging brains in studying alzheimer's disease: Modern ophthalmic data collection in the adult changes in thought (ACT) studyR01AG060942 · NIA · WASHINGTON UNIVERSITY · PI Cecilia Sungmin Lee · 2019 to 2026
$39.4MFurthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0MThe Late Effects of TBI (LETBI) Study: Injury Patterns and Biological Markers of Post-Traumatic NeurodegenerationRF1NS115268 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Kristen Dams-O'Connor · 2019 to 2026
$10.3MNeuroimaging and clinical Endpoints With High-dimensional analysis Of Pathological Endophenotypes in TBI (NEW-HOPE-TBI)U01NS137484 · NINDS · UNIVERSITY OF WASHINGTON · PI CHRISTOPHER DIRK KEENE, Christine L MacDonald · 2024 to 2026
$6.3MNeuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo DiagnosticsU01NS086625 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2014 to 2017
$6.1MLeveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)R01AG061028 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN, MEZ, JESSE BENJAMIN · 2019 to 2023
$5.9MClinical & biological signatures of post-traumatic neurodegeneration: Leveraging the TBI Model Systems of Care to accelerate in vivo diagnosis of the late effects of TBI (LETBI)RF1NS128961 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DAMS-O'CONNOR, KRISTEN · 2022 to 2022
$5.0MResearch Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0MNIA NIH HHS P30 AG066514NIA NIH HHS R01 AG060942NIA NIH HHS R01 AG061028NIA NIH HHS T32 AG049688NIA NIH HHS U01 AG006781NIA NIH HHS U19 AG066567NINDS NIH HHS RF1 NS115268NINDS NIH HHS RF1 NS128961NINDS NIH HHS U01 NS086625NINDS NIH HHS U01 NS137484
6 · The paper itselfAbstract
BackgroundTraumatic brain injury (TBI) is associated with increased dementia risk, yet its relationship to Alzheimer's disease (AD) neuropathology is unclear. Prior autopsy studies show inconsistent results, constrained by limited TBI ascertainment, semi-quantitative neuropathology methods, and selection bias.ObjectiveTo examine whether TBI with loss of consciousness (TBI-LOC) is associated with quantitative measures of tau and amyloid-β
Indexed as
Alzheimer DiseaseBrainBrain Injuries, TraumaticAgedAged, 80 and overAmyloid beta-PeptidesAutopsyCohort StudiesFemaleHumansMaleMiddle AgedPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide Fragmentstau ProteinsAlzheimer's diseaseautopsydementiatraumatic brain injury
Identifiers
PMID42300698
PMCPMC13309140
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