Evidence map›Paper›PMID 42300206›Full record

ArticleContact dermatitis2026

Methylchloroisothiazolinone and Methylisothiazolinone 10 Years After Regulation: A Case Story of Liquid Soaps and Shampoos.

Mathias Krogh Pedersen, Jakob Ferløv Baselius Schwensen, Jose Hernán Alfonso, Christel Søgaard Kirkeby, Stine Müller, Steen Mollerup, Gianluca Selvestrel, Christina Rudén, Martin F Wilks, Jeanne Duus Johansen

Abstract read
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In one paragraph

Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mathias Krogh PedersenThe National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology, Copenhagen University Hospital Herlev-Gentofte, Gentofte Hospital, Hellerup, Denmark.ORCID https://orcid.org/0009-0006-7185-2042
Jakob Ferløv Baselius SchwensenThe National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology, Copenhagen University Hospital Herlev-Gentofte, Gentofte Hospital, Hellerup, Denmark.ORCID https://orcid.org/0009-0007-9756-656X
Jose Hernán AlfonsoSection of Occupational Toxicology, National Institute of Occupational Health, Oslo, Norway.ORCID https://orcid.org/0000-0003-3504-2473
Christel Søgaard KirkebyThe Danish Consumer Council THINK Chemicals (Forbrugerrådet TAENK Kemi), Copenhagen, Denmark.
Stine MüllerThe Danish Consumer Council THINK Chemicals (Forbrugerrådet TAENK Kemi), Copenhagen, Denmark.
Steen MollerupSection of Occupational Toxicology, National Institute of Occupational Health, Oslo, Norway.
Gianluca SelvestrelEnvironmental Sustainability for Industrial and Health Systems Unit, Environmental Health Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.
Christina RudénDepartment of Environmental Science, Stockholm University, Stockholm, Sweden.
Martin F WilksDepartment of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
Jeanne Duus JohansenThe National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology, Copenhagen University Hospital Herlev-Gentofte, Gentofte Hospital, Hellerup, Denmark.ORCID https://orcid.org/0000-0002-3537-8463

Funding

EU's Horizon Europe research and innovation program 101057014
6 · The paper itself

Abstract

backgroundContact allergy to methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) remains common in the EU despite regulation.

objectivesTo assess the extent of use of MCI/MI and MI in cosmetic products on the Danish market, identify product categories involved and evaluate compliance of rinse-off products with the 15 ppm limit. MATERIALS AND

methodsProducts listing MCI/MI or MI were identified through Kemiluppen, a Danish database of marketed cosmetics. Thirty products (16 shampoos and 14 liquid soaps) were examined using liquid chromatography-tandem mass spectrometry: 25 labelled as containing MCI/MI or MI, 5 unlabelled.

resultsIn total, 257 cosmetic products containing MCI/MI or MI were identified, primarily shampoos (127), conditioners (98) and liquid soaps (8). Chemical analysis showed that 2 of 25 labelled products (8%) exceeded the 15 ppm limit, and 4 products did not meet the required 3:1 MCI/MI ratio.

conclusionMCI/MI is used infrequently in cosmetic products. All, except two products complied with the limit in the regulation. Given the continued occurrence of contact allergy, this indicates that the limit (15 ppm) may be too high to be sufficiently protective. Further investigation into MCI/MI use in cosmetic products is warranted, alongside more proactive risk assessment and management strategies.

Indexed as

CosmeticsDermatitis, Allergic ContactHair PreparationsThiazolesChromatography, LiquidConsumer Product SafetyDenmarkHumansProduct LabelingTandem Mass Spectrometry2-methyl-4-isothiazolin-3-one5-chloro-2-methyl-4-isothiazolin-3-oneCosmeticsHair PreparationsThiazolescontact allergycosmeticsmethylchloroisothiazolinonemethylisothiazolinone

Identifiers

PMID42300206
PMCPMC13551410

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.