Evidence map›Paper›PMID 42299878›Full record

ArticleVeterinary medicine and science2026

Efficacy of Vitex pseudo-negundo in a Bovine Mastitis Model Experimentally Induced by Staphylococcus aureus in Rats.

Hüseyin Koç, Arzu Fındık, Tolga Güvenç, Nevzat Batan, Seda Fandaklı, Murat Fındık

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Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hüseyin KoçDepartment of Veterinary Medicine, Vocational School of Maçka, Karadeniz Technical University, Trabzon, Türkiye.ORCID https://orcid.org/0000-0002-9031-6505
Arzu FındıkDepartment of Veterinary Microbiology, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Türkiye.ORCID https://orcid.org/0000-0002-9123-6160
Tolga GüvençDepartment of Veterinary Pathology, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Türkiye.ORCID https://orcid.org/0000-0003-1468-3415
Nevzat BatanDepartment of Molecular Biology and Genetics, Faculty of Science, Karadeniz Technical University, Trabzon, Türkiye.ORCID https://orcid.org/0000-0001-8456-5719
Seda FandaklıDepartment of Medical Services and Techniques, Vocational School of Health Services, Artvin Coruh University, Artvin, Türkiye.ORCID https://orcid.org/0000-0002-8199-3336
Murat FındıkDepartment of Veterinary Obstetrics and Gynecology, Faculty of Veterinary Medicine, Ondokuz Mayıs University, Samsun, Türkiye.ORCID https://orcid.org/0000-0003-1408-2548

Funding

TÜBİTAK 1002 124O594
6 · The paper itself

Abstract

backgroundMastitis is one of the most prevalent and economically significant diseases in dairy cattle, causing to inflammation of the mammary gland and reduced milk yield.

objectivesThis study investigated the therapeutic efficacy of Vitex pseudo-negundo (VPN) extracts in an experimentally induced rat mastitis model.

methodsSixty female Wistar rats were randomly assigned into six groups of 10. Group I served as the control group. Mastitis was induced by intramammary injection of Staphylococcus aureus (SA) (1.5 × 10

resultSA infection significantly increased mammary gland weight, total oxidative status (TOS) and bacterial load and induced tissue pathology, while decreasing total antioxidant status (TAS). C-reactive protein levels remained unchanged. VPN significantly improved mammary gland weight, TOS, TAS, bacterial load and histological parameters (p < 0.001). Mammary gland weight, oxidative stress, bacterial load and histopathological lesion severity all decreased markedly following treatment. Histological examination showed near-normal restoration of mammary gland architecture in all treatment groups.

conclusionPreparations of VPN, particularly the water extract, demonstrated strong potential for restoring altered microbiological, biochemical and histological parameters in this rat mastitis model.

Indexed as

Anti-Bacterial AgentsMastitisMastitis, BovinePlant ExtractsStaphylococcal InfectionsVitexAnimalsCattleDisease Models, AnimalFemaleMammary Glands, AnimalRandom AllocationRatsRats, WistarStaphylococcus aureusAnti-Bacterial AgentsPlant Extractsbacterial loadexperimental modelmastitisoxidative stressphytotherapyVitex pseudo‐negundo

Identifiers

PMID42299878
PMCPMC13270397

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.