ArticleJournal of hypertension2026
Can placental histology reveal preexisting hypertension in patients who develop preeclampsia?
Article in Journal of hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension can be both a cause and a consequence of preeclampsia, complicating diagnosis and postpartum management. Placental histopathology has been proposed as a tool to distinguish preeclampsia superimposed on chronic hypertension from de-novo disease, yet specific and reliable markers remain poorly defined.
objectiveTo evaluate the association between placental histological features and preexisting hypertension in a cohort of patients who developed preeclampsia.
methodsWe conducted a retrospective analysis of 321 preeclamptic pregnancies at a tertiary center between January 1, 2020, and October 31, 2023. Preexisting hypertension was defined as the use of antihypertensive medication at the beginning of pregnancy. Placental histopathological evaluation was available for 223 patients. Histological lesions were classified according to established guidelines, with a focus on maternal vascular malperfusion features. Associations between placental lesions and preexisting hypertension were assessed using univariate and multivariate analyses.
resultsThe absence of placental infarction (47.4 vs. 61.1%, P = 0.02) and the presence of decidual arteriopathy (31.6 vs. 16.8%, P = 0.03) were significantly associated with preexisting hypertension. The combination of these two features was independently associated with preexisting hypertension (odds ratio = 5.90; 95% confidence interval 1.88-18.60; P < 0.01). This pattern demonstrated high specificity (96.2%) but low sensitivity (18.4%) for identifying preexisting hypertension.
conclusionThe presence of decidual arteriopathy in the absence of placental infarction is strongly associated with preexisting hypertension in preeclamptic patients. Although its low sensitivity limits its use as a screening tool, its high specificity suggests that it may serve as a useful indicator of underlying chronic hypertension when present. These findings support the potential role of placental histopathology as an adjunct to clinical evaluation in the postpartum assessment of hypertensive disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.