Evidence map›Paper›PMID 42299714›Full record

ArticlePsychological medicine2026

Does gestational vitamin D attenuate the negative effects of prenatal depression on offspring emotional and behavioral problems? Findings in the ECHO cohort.

Alison E Hipwell, Irene Tung, Meredith Palmore, Melissa M Melough, Lisa M Bodnar, Lisa A Croen, Ashley V Hill, Traci A Bekelman, Patricia A Brennan, Kecia N Carroll and 4 more

Abstract read
In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alison E HipwellDepartment of Psychiatry, https://ror.org/01an3r305University of Pittsburgh, Pittsburgh, USA.ORCID https://orcid.org/0000-0001-7179-1151
Irene TungDepartment of Psychology, California State University, Dominguez Hills, Carson, USA.ORCID https://orcid.org/0000-0003-1263-066X
Meredith PalmoreDepartment of Epidemiology, https://ror.org/00za53h95Johns Hopkins University Bloomberg School of Public Health, Baltimore, USA.ORCID https://orcid.org/0000-0003-4801-8122
Melissa M MeloughDepartment of Health Behavior and Nutrition Sciences, https://ror.org/01sbq1a82University of Delaware, Newark, USA.ORCID https://orcid.org/0000-0003-1539-0980
Lisa M BodnarDepartment of Epidemiology, https://ror.org/01an3r305University of Pittsburgh School of Public Health, Pittsburgh, USA.ORCID https://orcid.org/0000-0001-9427-5467
Lisa A CroenDivision of Research, https://ror.org/00t60zh31Kaiser Permanente Northern California, Pleasanton, USA.
Ashley V HillDepartment of Community Health Sciences, https://ror.org/02mpq6x41University of Illinois Chicago School of Public Health, Chicago, USA.
Traci A BekelmanLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, USA.
Patricia A BrennanDepartment of Psychology, https://ror.org/03czfpz43Emory University, Atlanta, USA.ORCID https://orcid.org/0000-0003-3742-2891
Kecia N CarrollDepartment of Pediatrics, https://ror.org/04a9tmd77Icahn School of Medicine at Mount Sinai, New York, USA.
Rebecca J SchmidtDepartment of Public Health Sciences, MIND Institute, University of California, School of Medicine, Davis, USA.ORCID https://orcid.org/0000-0003-1582-2747
Emily ZimmermanDepartment of Communication Sciences and Disorders, https://ror.org/04t5xt781Northeastern University, Boston, USA.
Monica McGrathDepartment of Epidemiology, https://ror.org/00za53h95Johns Hopkins University Bloomberg School of Public Health, Baltimore, USA.
ECHO Cohort Consortium

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Linda S Adair, Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
ECHO Laboratory Core at Vanderbilt for Integrated Sample Biobanking and ProcessingU24OD035523 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Suman Ranjan Das, NATASHA Bassam HALASA · 2023 to 2026
$32.8M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Statistical Services and Methods Development ResourceU2CES026555 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GENNINGS, CHRIS · 2015 to 2025
$26.4M
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and NeurodevelopmentUH3OD023289 · OD · KAISER FOUNDATION RESEARCH INSTITUTE · PI ASSIAMIRA FERRARA, Monique Marie Hedderson · 2018 to 2026
$25.1M
Untargeted Analysis ResourceU2CES026561 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROBERT O · 2015 to 2025
$24.5M
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)UH3OD023251 · OD · NORTHEASTERN UNIVERSITY · PI Akram N Alshawabkeh · 2018 to 2026
$24.0M
Early Life Stress and the Environmental Origins of Disease: a Population-based Prospective Longitudinal Study of Children in Rural Poverty (ECHO)UH3OD023332 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KOPP, LISA MICHELLE, SWINGLER, MARGARET M. · 2018 to 2022
$22.7M
NIH HHS U24 OD023382NIH HHS UH3 OD023244NIH HHS UH3 OD023248NIH HHS UH3 OD023251NIH HHS UH3 OD023271NIH HHS UH3 OD023289NIH HHS UH3 OD023318NIH HHS UH3 OD023328NIH HHS UH3 OD023337NIH HHS UH3 OD035550NIH Office of the Director ES0266542NIH Office of the Director U24ES026539NIH Office of the Director U24OD023319NIH Office of the Director U24OD023382NIH Office of the Director U24OD035523NIH Office of the Director U2CES026533NIH Office of the Director U2CES026542NIH Office of the Director U2CES026555NIH Office of the Director U2CES026561NIH Office of the Director U2CES030851NIH Office of the Director U2CES030857NIH Office of the Director U2CES030859NIH Office of the Director U2COD023375NIH Office of the Director UG3OD035508NIH Office of the Director UG3OD035509NIH Office of the Director UG3OD035513NIH Office of the Director UG3OD035516NIH Office of the Director UG3OD035517NIH Office of the Director UG3OD035518NIH Office of the Director UG3OD035519NIH Office of the Director UG3OD035521NIH Office of the Director UG3OD035526NIH Office of the Director UG3OD035527NIH Office of the Director UG3OD035528NIH Office of the Director UG3OD035529NIH Office of the Director UG3OD035532NIH Office of the Director UG3OD035533NIH Office of the Director UG3OD035536NIH Office of the Director UG3OD035537NIH Office of the Director UG3OD035540NIH Office of the Director UG3OD035542NIH Office of the Director UG3OD035543NIH Office of the Director UG3OD035544NIH Office of the Director UG3OD035546NIH Office of the Director UG3OD035550NIH Office of the Director UG3/UH3OD023244NIH Office of the Director UG3/UH3OD023248NIH Office of the Director UG3/UH3OD023249NIH Office of the Director UG3/UH3OD023251NIH Office of the Director UG3/UH3OD023253NIH Office of the Director UG3/UH3OD023272NIH Office of the Director UG3/UH3OD023275NIH Office of the Director UG3/UH3OD023279NIH Office of the Director UG3/UH3OD023282NIH Office of the Director UG3/UH3OD023285NIH Office of the Director UG3/UH3OD023288NIH Office of the Director UG3/UH3OD023289NIH Office of the Director UG3/UH3OD023290NIH Office of the Director UG3/UH3OD023305NIH Office of the Director UG3/UH3OD023313NIH Office of the Director UG3/UH3OD023337NIH Office of the Director UG3/UH3OD023342NIH Office of the Director UG3/UH3OD023344NIH Office of the Director UG3/UH3OD023348NIH Office of the Director UG3/UH3OD023349NIH Office of the Director UG3/UH3OD023365NIH Office of the Director UG3/UH3OD023389NIH Office of the Director UH3OD023268NIH Office of the Director UH3OD023271NIH Office of the Director UH3OD023286NIH Office of the Director UH3OD023287NIH Office of the Director UH3OD023318NIH Office of the Director UH3OD023320NIH Office of the Director UH3OD023328NIH Office of the Director UH3OD023332NIH Office of the Director UH3OD023347
6 · The paper itself

Abstract

backgroundPrenatal depression is associated with offspring behavioral problems, but heterogeneity in the strength of this association is not well understood. Maternal vitamin D concentration during pregnancy is important for fetal brain development and may help explain this variability, with potential differences by timing of exposure and maternal race.

methodsUsing data from 1,451 mother-child pairs in the Environmental influences on Child Health Outcomes cohort, linear mixed-effects models examined associations between prenatal depressive symptom severity, gestational 25-hydroxy-vitamin D (25[OH]D) concentrations, and internalizing and externalizing behaviors in preschool-aged children. Analyses were stratified by common 25(OH)D deficiency thresholds, prenatal timing, and race.

resultsPrenatal depressive symptom severity was associated with greater child internalizing (

conclusionsPrenatal depressive symptoms showed robust associations with child behavioral problems, largely independent of gestational 25(OH)D. However, attenuated risk for internalizing behaviors with low vitamin D levels warrants investigation of social-environmental factors.

Indexed as

Child Behavior DisordersDepressionPregnancy ComplicationsPrenatal Exposure Delayed EffectsProblem BehaviorVitamin DVitamin D DeficiencyAdultChild, PreschoolCohort StudiesFemaleHumansMalePregnancy25-hydroxyvitamin DVitamin Ddepressionexternalizing and internalizing behaviorspregnancyvitamin D

Identifiers

PMID42299714
PMCPMC13280691

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.