ArticleAME case reports2026
Doege-Potter syndrome in a patient with solitary fibrous tumor of the pleura: a rare cause of refractory hypoglycemia-a case report.
Article in AME case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Solitary fibrous tumors of the pleura (SFTPs) are rare mesenchymal neoplasms that usually follow a benign clinical course. Infrequently, they present with Doege-Potter syndrome (DPS), a paraneoplastic condition characterized by recurrent non-insulin-mediated hypoglycemia caused by excessive secretion of incompletely processed insulin-like growth factor II. This entity is reported in fewer than 5% of cases and can lead to life-threatening metabolic disturbances. Case Description: A 65-year-old man presented with progressive dyspnea and recurrent refractory hypoglycemia. Chest radiography revealed a large opacity occupying the right hemithorax. Contrast-enhanced computed tomography demonstrated a well-circumscribed mass measuring approximately 18.8 cm × 15.1 cm × 18.2 cm causing compression of the right lung and mediastinal shift. Biochemical evaluation showed suppressed insulin and C-peptide levels, consistent with non-insulin-mediated hypoglycemia. Ultrasound-guided core biopsy suggested a spindle cell neoplasm. The patient underwent right anterolateral thoracotomy with complete surgical excision of the mass. Histopathological examination demonstrated a solitary fibrous tumor with spindle cells in a collagenous stroma, and immunohistochemistry showed strong positivity for CD34 and STAT6, confirming the diagnosis. Hypoglycemic episodes resolved immediately following tumor resection. The postoperative course was uneventful, and surveillance imaging demonstrated no recurrence at 3-year follow-up. Conclusions: A systematic approach is essential in the management of DPS, a rare but potentially aggressive paraneoplastic condition. Complete surgical resection remains the treatment of choice and typically results in rapid metabolic resolution. As the role of adjuvant therapy is not yet well established, accurate histopathological evaluation, appropriate risk stratification, and long-term surveillance are crucial to optimize outcomes and detect recurrence early.
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