Observational studyBiochemia medica2026
Factors associated with Gla-rich protein serum concentrations in healthy adults.
Observational study in Biochemia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Introduction: Gla-rich protein (GRP) is a vitamin K-dependent protein involved in the regulation of ectopic calcification and inflammatory processes. However, data on circulating GRP concentrations in healthy adults remain limited. Materials and methods: This cross-sectional observational study evaluated serum total GRP (tGRP) concentrations in 254 healthy adult blood donors (48% male), aged 18-65 years, using a sandwich enzyme-linked immunosorbent assay (ELISA) (GenoGla Diagnostics, Faro, Portugal). Participants were stratified by age tertiles, and associations between serum tGRP concentrations and demographic and laboratory parameters were assessed using non-parametric statistical tests, Spearman correlation, and stepwise linear regression. Results: The median serum tGRP concentration in the overall population was 1809.5 pg/mL (interquartile range: 1197.4-2476.0 pg/mL). Serum tGRP concentrations differed significantly across age tertiles (P = 0.038), with higher concentrations observed in younger adults. Serum tGRP concentrations showed a weak but statistically significant inverse correlation with age (r = - 0.30, P = 0.001), while no significant differences were observed between sexes (P = 0.420). In multivariable analysis, age and serum calcium concentration remained independently associated with serum tGRP concentrations, jointly explaining approximately 7% of their variability. Conclusion: This study establishes robust reference data for circulating tGRP concentrations in healthy adults, providing a foundation for the interpretation of GRP measurements in future clinical and epidemiological research.
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