ArticleBiochemia medica2026
Verification of harmonized reference intervals in Croatia: is it time for a change?
Article in Biochemia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The study of harmonized reference intervals (RIs) in Croatia was published in 2004. Since then, notable methodology and population characteristics changes have occurred in the Croatian population, highlighting the need for re-evaluation. This study aimed to verify harmonized RIs for hematology, coagulation, and clinical chemistry laboratory tests and assess their applicability in one clinical hospital center. Materials and methods: This verification study included 100 apparently healthy adults (40 males, 60 females; aged 22 to 75 years), selected using both Results: All tested hematology and coagulation RIs were successfully verified. Among 27 tested biochemical analytes, 25 RIs were verified in the first sample set. Total calcium and alkaline phosphatase RIs required additional verification. International harmonized RIs were adopted and successfully verified for both tests using two independent sample sets. Conclusions: Most harmonized RIs in use in Croatia remain applicable to the adult population of one clinical hospital center. However, periodic re-evaluation is needed due to changes in analytical methods and population characteristics. Reference intervals from international harmonization projects can provide a valid alternative when local verification fails.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.