Evidence map›Paper›PMID 42299320›Full record

ArticleJournal of the Endocrine Society2026

Transient gonadotropin suppression by exogenous testosterone decreases INSL3 in early puberty in boys with constitutional delay of growth and puberty.

Taneli Raivio, Mila Tanner, Kirsi Vaaralahti, Matti Hero, Päivi J Miettinen, Tero Varimo

Abstract read
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Taneli RaivioNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, 00290 Helsinki, Finland.ORCID https://orcid.org/0000-0001-5385-434X
Mila TannerNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, 00290 Helsinki, Finland.
Kirsi VaaralahtiNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, 00290 Helsinki, Finland.
Matti HeroNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, 00290 Helsinki, Finland.
Päivi J MiettinenNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, 00290 Helsinki, Finland.
Tero VarimoNew Children's Hospital, Helsinki University Hospital, Pediatric Research Center, 00290 Helsinki, Finland.ORCID https://orcid.org/0000-0002-6294-4563

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated circulating insulin-like peptide 3 (INSL3) in boys with constitutional delay of growth and puberty treated with exogenous testosterone (T) or oral letrozole (Lz). Twenty-eight boys were randomized to Lz (2.5 mg/day;

Indexed as

adolescent maleCDGPexogenous testosteroneINSL3letrozolepuberty

Identifiers

PMID42299320
PMCPMC13265132

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.