ArticleJournal of pain research2026
Genomic Research for Abdominal Pain in Patients with Irritable Bowel Syndrome or Inflammatory Bowel Disease Before and After Mind-Body Intervention.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Purpose: Abdominal pain is a hallmark symptom of both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and substantially impairs patients' quality of life. Relaxation response-based mind-body intervention (RR-MBI) has been reported to improve disease-specific outcomes and pain catastrophizing in both disorders, accompanied by whole-blood transcriptomic changes. However, the transcriptional features potentially relevant to abdominal pain before and after RR-MBI in IBS and IBD remain insufficiently explored. In this context, this study aimed to analyze these transcriptional changes and prioritize putative abdominal pain-relevant candidate genes from exploratory differentially expressed gene (DEG) sets. Patients and Methods: Gene expression data (GSE66824) were obtained from the Gene Expression Omnibus (GEO). Whole-blood gene expression profiles were analyzed from 14 IBS and 19 IBD patients, with samples collected before and after a 9-week RR-MBI. Exploratory DEG sets were identified using GEO2R outputs with nominal P < 0.05 and absolute fold-change magnitude (AFC) ≥ 1.2. Functional enrichment analyses were performed using DAVID. Protein-protein interaction (PPI) networks were constructed using STRING and visualized in Cytoscape. Putative abdominal pain-relevant candidate genes were prioritized from exploratory DEG sets within PPI/MCODE modules based on network position, matching module genes to the DisGeNET disease entry "pain", and targeted pain-related literature annotation. Results: (1) In IBD post-MBI, 649 exploratory DEGs were identified, with enrichment of neurotrophin and TGF-β signaling pathways; MAP3K7, SLC12A2, and FKBP5 were prioritized as candidate genes. (2) In IBS post-MBI, 175 exploratory DEGs were identified, with enrichment of glutamatergic synapse and calcium signaling pathways; network analysis highlighted NTRK2, FKBP5, and AR as candidate genes. (3) At baseline, 836 exploratory DEGs were identified, with enrichment in pathways including p53 signaling and NOD-like receptor signaling; notable prioritized candidate genes included TRAF6 and TNFSF11. Conclusion: Prioritized genes after RR-MBI and in the baseline comparison may represent putative abdominal pain-relevant candidate transcriptional signals in IBS and IBD. These exploratory findings require validation in independent cohorts with matched individual-level pain-related outcomes and functional studies.
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