Evidence map›Paper›PMID 42299149›Full record

ArticlePeerJ2026

Effect of hypoalbuminemia on postoperative pulmonary complications after thoracoscopic anatomical lung resection: a retrospective cohort study.

Mengmeng Xu, Jie Sun, Menghan Sun

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Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Mengmeng XuDepartment of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui Province, China.
Jie SunDepartment of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Menghan SunDepartment of Anesthesiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Anatomical segmental resection is a standard treatment for non-small cell lung cancer but frequently entails postoperative pulmonary complications (PPCs). Serum albumin level, as useful assessment of changes in nutritional status, is closely associated with postoperative outcomes. Therefore, we evaluated the impact of preoperative albuminemia level on PPCs in thoracoscopic anatomical lung resection. Methods: We conducted a retrospective analysis of clinical data from 1,192 patients who underwent elective thoracoscopic anatomical lung resection owing to pulmonary tumors or other diseases at the First Affiliated Hospital of Nanjing Medical University between January 2020 and December 2020. Patients were stratified into a hypoalbuminemia group (<35 g/L) and a normal albumin group (≥35 g/L) based on the lowest albumin concentration in the 48 h before operation. Demographics, perioperative data, and PPCs incidence were compared between groups. Propensity score matching (PSM) was employed to balance baseline characteristics, after which PPCs incidence was recompared. Multivariate regression was performed to assess excess risks for PPCs associated with hypoalbuminemia, adjusted for demographics and clinical variables. Results: Among the 1,192 patients included, the overall incidence rate of PPCs was 26.7% (319/1,192), with pneumonia being the most common complication (16.0%). Preoperative hypoalbuminemia was present in 224 patients (18.8%). After PSM, the hypoalbuminemia group had a significantly higher incidence of PPCs compared to the normal albumin group ( Conclusion: Preoperative hypoalbuminemia is an independent predictor of PPCs, particularly pneumonia, in patients with normal pulmonary function undergoing thoracoscopic anatomical lung resection.

Indexed as

Carcinoma, Non-Small-Cell LungHypoalbuminemiaLung NeoplasmsPneumonectomyPostoperative ComplicationsThoracoscopyAgedFemaleHumansIncidenceMaleMiddle AgedPneumoniaPropensity ScoreRetrospective StudiesRisk FactorsPostoperative pulmonary complicationsPropensity score matchingRisk factors

Identifiers

PMID42299149
PMCPMC13264973

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.