ArticleJournal of Korean medical science2026
Sex Differences in the Effect of Long-Term Blood Pressure Trajectories and Variability on the Atrial Fibrillation Risk in a Korean Cohort.
Article in Journal of Korean medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLong-term blood pressure (BP) patterns and variability may influence atrial fibrillation (AF) risk. However, whether these associations differ according to sex is unclear.
methodsWe analyzed 45,663 adults (age ≥ 40 years) from a Korean National Health Insurance cohort. Over the past decade, systolic BP (SBP) trajectories have been classified into two distinct trajectory classes: Class 1 (stable-low BP) and Class 2 (sustained-elevated BP). Visit-to-visit SBP variability, quantified as variability independent of the mean (VIM), was stratified into quartiles. The participants were followed up for incident AF between 2012 and 2019. Using sex-stratified Cox proportional hazards models, we assessed the association of SBP trajectory class and VIM with AF risk.
resultsMale sex (adjusted hazard ratio [HR], 1.43;
conclusionLong-term SBP trajectories and variability demonstrated sex-specific effects on AF risk. An elevated SBP trajectory and high variability conferred an increased risk of AF in men, but not in women. This novel finding may provide new insights into sex-specific differences in the pathogenesis of AF.
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