Evidence map›Paper›PMID 42298822›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

Increasing intrinsic protein disorder improves CD8+ immunogenicity for a SARS CoV2 vaccine candidate antigen.

Li Wan, Bingxian Xie, Masahiro Shuda, Maura E O'Malley, Carlos J Camacho, Greg M Delgoffe, Yuan Chang, Patrick S Moore

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li WanCancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Bingxian XieImmunology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Masahiro ShudaCancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Maura E O'MalleyDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Carlos J CamachoDepartment of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Greg M DelgoffeImmunology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.
Yuan ChangCancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA. Electronic address: yc70@pitt.edu.
Patrick S MooreCancer Virology Program, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA. Electronic address: psm9@pitt.edu.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Uncovering the metabolic underpinnings of T cell exhaustionR01AI166598 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2022 to 2025
$3.2M
Dissecting the role of hypoxia in T cell differentiation in cancerR01CA277473 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe, Yana Najjar · 2023 to 2026
$2.4M
Metabolic control of regulatory T cell functional identityR01AI171483 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELGOFFE, GREG M. · 2022 to 2025
$2.4M
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA277473NIAID NIH HHS R01 AI166598NIAID NIH HHS R01 AI171483
6 · The paper itself

Abstract

CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI) that inhibits in cis RdRp-derived peptide presentation on major histocompatibility complex class I. We show that this is related to the highly ordered nature of RdRp, which can be reversed by dividing RdRp into two intrinsically disordered, complementary sub-fragments (RdRp

Indexed as

Antigens, ViralCD8-Positive T-LymphocytesCOVID-19COVID-19 VaccinesRNA-Dependent RNA PolymeraseSARS-CoV-2AnimalsCricetinaeEpitopes, T-LymphocyteFemaleHumansMiceProtein Subunit VaccinesAntigens, ViralCOVID-19 VaccinesEpitopes, T-LymphocyteProtein Subunit VaccinesRNA-Dependent RNA Polymeraseimmune evasionintrinsic disorderMHC I presentationRdRp/nsp12SARS CoV2vaccine

Identifiers

PMID42298822
PMCPMC13555547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.