ArticleCurrent medical imaging2025
The Relationship between Glymphatic Dysfunction and Post-stroke Cognitive Impairment.
Article in Current medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review.Frontiers in immunology · 2026Pooled it
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlymphatic dysfunction is proposed as a final common pathway to dementia. Cognitive impairment following ischemic stroke can gradually worsen, potentially leading to post-stroke dementia. This study aimed to examine the changes in glymphatic function in post-stroke patients and explore its relationship with cognition.
methodsA total of thirty-two post-stroke patients and twenty-seven healthy controls (HCs) matched for age, sex, and educational level were enrolled in this study. All participants underwent neurological MRI scans and comprehensive cognitive assessments six months following the onset of the stroke. Three glymphatic markers derived from MRI were quantified, including diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, choroid plexus volume (CPV), and enlarged perivascular spaces (PVS) volume. The changes in glymphatic markers and their correlations with cognitive scores were analyzed.
resultsPost-stroke patients exhibited a significantly decreased DTI-ALPS index (p < 0.001) and an increased CPV ( DISCUSSION: The findings demonstrated that glymphatic dysfunction, as indicated by a reduced DTI-ALPS index and increased CPV volume, was evident in post-stroke patients and significantly linked to impairments in specific cognitive domains, including working memory, processing speed, and executive function. These observations supported the hypothesis that glymphatic impairment may represent a key mechanistic pathway underlying post-stroke cognitive impairment (PSCI). To further elucidate the causal relationships and identify potential therapeutic targets, future studies incorporating larger cohorts, longitudinal designs, and region-specific PVS analyses are warranted.
conclusionPost-stroke patients exhibited a reduced DTI-ALPS index and an increased CPV, potentially reflecting impaired glymphatic function. Furthermore, these metrics were associated with specific cognitive domains.
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