ReviewBritish journal of clinical pharmacology2026
Mineralocorticoid magic? Evaluating fludrocortisone in septic shock.
Review in British journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mineralocorticoid magic? Evaluating fludrocortisone in septic shock.British journal of clinical pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of adjunctive steroids for septic shock has been controversial since the turn of the century. The largest clinical trial evaluating adjunctive corticosteroids in septic shock failed to report a mortality benefit while comparing a continuous intravenous hydrocortisone infusion to placebo despite shortening the time to shock resolution. Alternatively, two clinical trials evaluating a combination of intravenous hydrocortisone and enteral fludrocortisone in septic shock reported a mortality benefit. Robust data on the outcomes associated with the addition of fludrocortisone to hydrocortisone compared to hydrocortisone alone are sparse. Likewise, significant practice variation exists regarding the prescription of steroids for septic shock. For this manuscript, we completed a comprehensive search of the utility of the combination of fludrocortisone and hydrocortisone for the management of septic shock. The purpose of the review is to explore the pharmacology, pharmacokinetics and pharmacodynamics of fludrocortisone and to evaluate the present literature to aid clinicians in making personalized treatment decisions for this controversial topic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.