Evidence map›Paper›PMID 42298686›Full record

ArticleJournal of neuroinflammation2026

A brain-lung circuit drives LPS-induced lung injury via sympathetic neutrophil axis.

Shichun Ren, Shuo Yang, Baotong Liu, Qian Zhang, Zhenzhen Zhao, Yan Meng, Qi Shao, Xiaoming Deng, Jinjun Bian, Li Cao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shichun Ren *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Shuo Yang *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Baotong Liu *Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Qian ZhangDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Zhenzhen ZhaoDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Yan MengDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Qi ShaoInstitute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China.
Xiaoming DengDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jinjun BianDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Li CaoInstitute of Neuroscience and Key Laboratory of Molecular Neurobiology of Military of Education, Naval Medical University, Shanghai, 200433, China. caoli@smmu.edu.cn.
Fengfeng MoDepartment of Naval Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China. mofengfeng@smmu.edu.cn.
Jiafeng WangDepartment of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. jfwang@smmu.edu.cn.

Funding

National Natural Science Foundation of China 32100935National Natural Science Foundation of China 82272214National Natural Science Foundation of China 82371357National Natural Science Foundation of China 82472186National Natural Science Foundation of China 82502617Sci-Tech Innovation 2030 Brain Science and Brain-Like Intelligence Technology Project 2022ZD0208100
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is a fatal complication of sepsis. However, the neural mechanisms underlying the exacerbation of pulmonary inflammation during systemic infection remain largely undefined. We employed an intraperitoneal lipopolysaccharide (LPS)-induced systemic inflammatory lung injury model and found that systemic inflammation strongly activates corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN), whereas bilateral subdiaphragmatic vagotomy abolished this response. Chemogenetic inhibition of CRH

Indexed as

BrainLipopolysaccharidesLungLung InjuryNeutrophilsSympathetic Nervous SystemAnimalsHumansMaleMiceMice, Inbred C57BLReceptors, Adrenergic, beta-2Respiratory Distress SyndromeSignal TransductionLipopolysaccharidesReceptors, Adrenergic, beta-2ALIARDSNeutrophilsPI3K/Akt signaling pathwaySepsisSympathetic nerveβ2-Adrenergic receptors

Identifiers

PMID42298686
PMCPMC13501785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.