Evidence map›Paper›PMID 42298683›Full record

ArticleJournal of neuroinflammation2026

Nipah virus infects the brain and triggers neuronal and glial damage in a hamster model.

Karl Valerdi, Takeshi Saito, Ruchi Paroha, Kirsten Littlefield, Jessica Plante, Kenneth Plante, Silvana Valdebenito, Junki Maruyama, Eliseo Eugenin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Karl ValerdiDepartment of Neurobiology, University of Texas Medical Branch, Research Building 17, 105 11th Street, Galveston, TX, 77550, USA.
Takeshi SaitoDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, 77550, USA.
Ruchi ParohaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, 77550, USA.
Kirsten LittlefieldDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77550, USA.
Jessica PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77550, USA.
Kenneth PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77550, USA.
Silvana ValdebenitoDepartment of Neurobiology, University of Texas Medical Branch, Research Building 17, 105 11th Street, Galveston, TX, 77550, USA.
Junki MaruyamaDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, 77550, USA. jumaruya@utmb.edu.
Eliseo EugeninDepartment of Neurobiology, University of Texas Medical Branch, Research Building 17, 105 11th Street, Galveston, TX, 77550, USA. eleugeni@utmb.edu.

Funding

Role of pannexin-1 hemichannels in NeuroAIDSR01NS105584 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2017 to 2021
$3.2M
Metabolic strategies to eliminate CNS Myeloid Viral ReservoirsR01MH128082 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI EUGENIN, ELISEO A · 2021 to 2025
$3.1M
Tunneling nanotubes are a novel mechanism for the propagation of HIV infection and neurodegenerationK01NS137812 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Silvana A Valdebenito-Silva · 2024 to 2026
$592k
Utilizing a novel hamster model to determine neurologic and behavioral abnormalities of offspring from mothers infected with SARS-CoV-2R21NS140036 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Eliseo A Eugenin, Kenneth Steven Plante · 2025 to 2026
$440k
NIMH NIH HHS MH128082NIMH NIH HHS R01 MH128082NINDS NIH HHS K01 NS137812NINDS NIH HHS NS105584NINDS NIH HHS NS137812NINDS NIH HHS NS140036NINDS NIH HHS R01 NS105584NINDS NIH HHS R21 NS140036University of Texas Medical Branch Start packageUniversity of Texas Medical Branch Start Package
6 · The paper itself

Abstract

Nipah virus (NiV) is distributed in South-East Asia and the Western Pacific, with currently active outbreak sites. NiV causes an acute febrile illness with high mortality (40-70%), encephalitis, and long-term disability among survivors. Currently, there are no effective therapeutic or preventive interventions, and its potential for explosive spread resulted in its designation as a pathogen of international epidemiological concern. However, the pathophysiology of NiV-induced encephalitis remains unclear. Using a hamster model of NiV infection, we demonstrated that NiV targets several brain areas, such as the cortex and the hippocampus, infecting neurons, astrocytes, and blood-brain barrier cells. NiV infection also induced glial activation, including both microglia and astrocytes, leading to vascular and neuronal compromise and parenchymal lesions. Overall, NiV demonstrates a marked tropism for the central nervous system, resulting in major damage and death.

Indexed as

BrainHenipavirus InfectionsNeurogliaNeuronsNipah VirusAnimalsCricetinaeDisease Models, AnimalMesocricetusAstrocytesEncephalitisMicrogliaNeurodegenerationNeuroinflammationNeuronsVirus

Identifiers

PMID42298683
PMCPMC13495180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.