Evidence map›Paper›PMID 42298670›Full record

ArticleActa neuropathologica communications2026

Methamphetamine hijacks chaperone-mediated autophagy to degrade GPX4, driving ferroptosis-precipitated cognitive decline and addictive pathogenesis.

Zizhen Si, Dan Zhu, Jianan Lv, Yang Shen, Xidi Wang, Jiahui Zhou, Zhiting Zou, Wenting Wei, Longhui Li, Xing Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zizhen SiDepartment of Psychiatry, Zhejiang Key Laboratory of Drug Addiction and Brain Health, The Affiliated Kangning Hospital of Ningbo University, Ningbo, China.
Dan ZhuHealth Science Center, Ningbo University, 818 Fenghua Road Jiangbei Dist, Ningbo, 315211, Zhejiang, P.R. China.
Jianan LvHealth Science Center, Ningbo University, 818 Fenghua Road Jiangbei Dist, Ningbo, 315211, Zhejiang, P.R. China.
Yang ShenAddiction treatment laboratory of Zhejiang, Hangzhou, China.
Xidi WangHealth Science Center, Ningbo University, 818 Fenghua Road Jiangbei Dist, Ningbo, 315211, Zhejiang, P.R. China.
Jiahui ZhouHealth Science Center, Ningbo University, 818 Fenghua Road Jiangbei Dist, Ningbo, 315211, Zhejiang, P.R. China.
Zhiting ZouDepartment of Psychology, Collage of Teacher Education, Ningbo University, Ningbo, China.
Wenting WeiSchool of Material Science and Chemical Engineering, Ningbo University, Ningbo, China.
Longhui LiDepartment of Psychiatry, Zhejiang Key Laboratory of Drug Addiction and Brain Health, The Affiliated Kangning Hospital of Ningbo University, Ningbo, China.
Xing XuZhejiang Rongjun Rehabilitation Hospital, Ningbo Psychiatric Hospital, Ningbo, China.
Yaping ChenZhejiang Rongjun Rehabilitation Hospital, Ningbo Psychiatric Hospital, Ningbo, China.
Wenhua ZhouDepartment of Psychiatry, Zhejiang Key Laboratory of Drug Addiction and Brain Health, The Affiliated Kangning Hospital of Ningbo University, Ningbo, China.
Yu LiuHealth Science Center, Ningbo University, 818 Fenghua Road Jiangbei Dist, Ningbo, 315211, Zhejiang, P.R. China. Liuyu@nbu.edu.cn.

Funding

Li Dasan and Ye Yaozhen Couple Li Benjun Marine Biomedicine R&D Fund of Ningbo University 2025-02National Natural Science Foundation of China 82301680Ningbo Science Foundation 2022S075Ningbo Yongjiang 2035 Research Project 2024Z190the Young Doctor Innovation Research Program of Ningbo 2024J469
6 · The paper itself

Abstract

Methamphetamine (METH) addiction is associated with progressive cognitive decline and maladaptive behaviors, but the molecular mechanisms bridging proteostatic dysfunction to neural circuit degeneration remain poorly defined. We hypothesized that METH hijacks chaperone-mediated autophagy (CMA), a lysosomal quality-control pathway, to drive neurodegeneration through ferroptosis. Using chronic METH self-administration models, hippocampal neurons, and CMA-targeted approaches, we demonstrated that METH coerces CMA components (HSC70-LAMP2A) to recognize a non-canonical

Indexed as

Central Nervous System StimulantsChaperone-Mediated AutophagyCognitive DysfunctionFerroptosisMethamphetaminePhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsHippocampusMaleMiceMice, Inbred C57BLNeuronsCentral Nervous System Stimulantsglutathione peroxidase 4, mouseMethamphetaminePhospholipid Hydroperoxide Glutathione PeroxidaseAddictive PathogenesisChaperone-mediated autophagyFerroptosisMethamphetamineSelf-administration

Identifiers

PMID42298670
PMCPMC13501791

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.