Evidence map›Paper›PMID 42298535›Full record

ArticleBMC oral health2026

Dentin tubule penetration of a calcium silicate-based sealer after removal of calcium hydroxide or N-acetylcysteine medicaments: an in vitro study.

Sude Coşar, Merve Sarı

Abstract read
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Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sude CoşarDepartment of Endodontics, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey.ORCID 0009-0008-1937-0622
Merve SarıDepartment of Endodontics, Faculty of Dentistry, Hatay Mustafa Kemal University, Hatay, Turkey. sarimerve94@outlook.com.ORCID 0000-0002-9432-3809

Funding

Hatay Mustafa Kemal University Scientific Research Projects 24.DHU.002
6 · The paper itself

Abstract

backgroundThis study aimed to evaluate, using confocal laser scanning microscopy (CLSM), the dentin tubule penetration of a calcium silicate-based root canal sealer after removal of calcium hydroxide (Ca(OH)

methodsRoot canals of 128 extracted single-rooted mandibular premolars were prepared with ProTaper Next. Canals received Ca(OH)

resultsNeither the type of intracanal medicament nor the activation technique significantly affected the residual medicament amount (p > 0.05). However, the type of medicament significantly influenced sealer penetration, with NAC showing greater dentin tubule penetration than Ca(OH)₂ (p < 0.05). The activation technique did not significantly influence sealer penetration (p > 0.05). Sealer penetration was highest in the coronal third and lowest in the apical third (p < 0.05).

conclusionWithin the limitations of this in vitro study, NAC enhanced the dentin tubule penetration of a calcium silicate-based sealer compared with Ca(OH)₂. The activation technique did not affect sealer penetration or residual medicament.

Indexed as

AcetylcysteineCalcium CompoundsCalcium HydroxideDentinDentin PermeabilityRoot Canal Filling MaterialsRoot Canal IrrigantsSilicatesBicuspidDrug CombinationsHumansMaterials TestingMicroscopy, ConfocalRoot Canal ObturationRoot Canal PreparationAcetylcysteineCalcium CompoundsCalcium Hydroxidecalcium silicateDrug CombinationsRoot Canal Filling MaterialsRoot Canal IrrigantsSilicatesCalcium hydroxideCalcium silicate–based sealerConfocal laser scanning microscopyN-acetylcysteine

Identifiers

PMID42298535
PMCPMC13523325

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.