Evidence map›Paper›PMID 42298529›Full record

ReviewBMC ophthalmology2026

Bilateral microsporidial keratoconjunctivitis in an orthokeratology lens wearer: a case report and literature review.

Rongbin Liang, Bei Zhang

Abstract readCase ReportsReview
In one paragraph

Review in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rongbin LiangDepartment of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchun East Road, Hangzhou, 310016, China.
Bei ZhangDepartment of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchun East Road, Hangzhou, 310016, China. 3100014@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMicrosporidial keratoconjunctivitis is a rare but serious ocular infection that can occur in contact lens wearers, particularly in individuals exposed to certain environmental or behavioral risk factors. Early and accurate diagnosis is crucial to ensure effective treatment and prevent long-term complications. This report presents a case of bilateral microsporidial keratoconjunctivitis in a pediatric patient who wore orthokeratology lenses, accompanied by a review of relevant literature. CASE PRESENTATION: A 9-year-old female presented with bilateral eye redness and a persistent foreign body sensation lasting for 3 weeks. The patient had recently started raising a pet parrot at home. Upon examination, conjunctival congestion was observed, along with papillary and follicular hypertrophy and diffuse punctate staining of the corneal epithelium. Corneal scraping and gene sequencing confirmed the diagnosis of Encephalitozoon hellem infection.

conclusionThis case underscores the rare occurrence of bilateral microsporidial keratoconjunctivitis in an immunocompetent child wearing orthokeratology lenses. Environmental exposure and lens wear may have contributed to infection. Clinicians should consider microsporidiosis in the differential diagnosis of persistent keratoconjunctivitis that does not respond to conventional therapies.

Indexed as

Contact LensesEncephalitozoonEncephalitozoonosisEye Infections, FungalKeratoconjunctivitisOrthokeratologic ProceduresChildFemaleHumansEncephalitozoon hellemGene sequencingOcular infectionOrthokeratology

Identifiers

PMID42298529
PMCPMC13495470

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.