Evidence map›Paper›PMID 42298501›Full record

ArticleBMC public health2026

"Safer supply is the thing that changes everything": the role of prescribed safer supply in rebuilding trust following experiences of medical abandonment.

Gillian Kolla, Bernie Pauly, Nancy Henderson, Fred Cameron, Kim Toombs, Emily Clayton, Josh Irvine, Corey Ranger, Lisbet Rygnestad, Andrea Sereda and 1 more

Abstract read
In one paragraph

Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gillian KollaCanadian Institute for Substance Use Research, University of Victoria, Victoria, Canada. gkolla@mun.ca.
Bernie PaulyCanadian Institute for Substance Use Research, University of Victoria, Victoria, Canada.
Nancy HendersonCanadian Institute for Substance Use Research, University of Victoria, Victoria, Canada.
Fred CameronSOLID Outreach, Victoria, Canada.
Kim ToombsAVI Health and Community Services, Victoria, Canada.
Emily ClaytonAVI Health and Community Services, Victoria, Canada.
Josh IrvineSOLID Outreach, Victoria, Canada.
Corey RangerAVI Health and Community Services, Victoria, Canada.
Lisbet RygnestadAVI Health and Community Services, Victoria, Canada.
Andrea SeredaLondon Intercommunity Health Centre, London, Canada.
Karen UrbanoskiCanadian Institute for Substance Use Research, University of Victoria, Victoria, Canada.

Funding

CIHR EV1-174804Health Canada Substance Use and Addiction Program
6 · The paper itself

Abstract

backgroundPrescribed safer supply provides people dependent on street-acquired opioids with pharmaceutical opioids to reduce overdose risk. Previous experience with the healthcare system - including opioid agonist treatment or high-dose opioids prescribed for pain - is common among people dependent on unregulated opioids, as are experiences of significant stigma when seeking care. Our objective was to examine previous healthcare experiences and how these differ from receiving care in safer supply programs.

methodsUsing reflexive thematic methods, qualitative interviews and focus groups were conducted in 2022 with 38 clients and 10 staff members from two prescribed safer supply programs in different parts of Canada: in London, Ontario and Victoria, British Columbia. Thematic analysis was used to examine themes related to experiences with the healthcare system both prior to initiating safer supply, and following engagement in care in a safer supply program.

resultsPrior to safer supply, participants described three trajectories of medical abandonment: abrupt deprescribing of high-dose opioids despite significant medical complexity, punitive and inadequate opioid agonist treatment, and pervasive stigma in healthcare settings. These experiences left participants deeply mistrustful of healthcare providers and forced to source opioids from the unregulated drug supply. Safer supply programs facilitated re-engagement in care through environments of trust and respect, with provision of opioids as a crucial step toward addressing complex health conditions and achieving social stabilization. DISCUSSION: Safer supply programs meet a critical need for comprehensive substance use care, reducing overdose risk while supporting management of complex medical conditions and social stabilization. For people previously deprescribed from opioid medications, prescribed safer supply assists in repairing trust and facilitating broader healthcare engagement. Our results caution against punitive, surveillance-oriented practices within safer supply prescribing, as these risk replicating the medical abandonment that created the need for alternative care models in the first place.

Indexed as

Analgesics, OpioidDrug OverdoseOpioid-Related DisordersTrustAdultBritish ColumbiaDeprescriptionsFemaleFocus GroupsHumansInterviews as TopicMaleOntarioQualitative ResearchSocial StigmaAnalgesics, OpioidDeprescribingMedical abandonmentMedications for opioid use disorderOpioid agonist treatmentOpioidsOverdoseSafer supply

Identifiers

PMID42298501
PMCPMC13393762

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.